Tyrosine-ester sulfotransferase
| Tyrosine-ester sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.2.9 | ||||||||
| CAS no. | 9055-56-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Tyrosine-ester sulfotransferase (EC 2.8.2.9) is an enzyme that catalyzes the chemical reaction
The reaction converts methyl L-tyrosine methyl ester to L-tyrosine methyl ester 4-sulfate by transferring a sulfate group from the cofactor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) and giving adenosine 3',5'-bisphosphate as a byproduct. The enzyme was characterised from rat liver.[1][2][3]
This enzyme is a transferase, specifically a sulfotransferase, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase. Other names in common use include aryl sulfotransferase IV, and L-tyrosine methyl ester sulfotransferase.[4]
References
- ↑ Mattock P, Jones JG (1970). "Partial purification and properties of an enzyme from rat liver that catalyses the sulphation of L-tyrosyl derivatives". Biochem. J. 116 (5): 797–803. doi:10.1042/bj1160797. PMC 1185501. PMID 5441369.
- ↑ Duffel MW, Jakoby WB (1981). "On the mechanism of aryl sulfotransferase". J. Biol. Chem. 256 (21): 11123–7. doi:10.1016/S0021-9258(19)68565-0. PMID 6945304.
- ↑ Sekura RD, Jakoby WB (1981). "Aryl sulfotransferase IV from rat liver". Arch. Biochem. Biophys. 211 (1): 352–9. doi:10.1016/0003-9861(81)90464-1. PMID 6946725.
- ↑ Enzyme 2.8.2.9 at KEGG Pathway Database.