Scymnol sulfotransferase
| Scymnol sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.2.32 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Scymnol sulfotransferase (EC 2.8.2.32) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from the Port Jackson shark uses the cofactor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to convert the bile salt, scymnol, to its sulfate derivative, giving adenosine 3',5'-bisphosphate as a byproduct.[1][2][3] The enzyme has also been found in Australian ray species.[4]
This enzyme is a transferase, specifically a sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-Phosphoadenosine-5'-phosphosulfate:5beta-scymnol sulfotransferase.[5]
References
- ↑ Macrides TA, Faktor DA, Kalafatis N, Amiet RG (1994). "Enzymic sulfation of bile salts. Partial purification and characterization of an enzyme from the liver of the shark Heterodontus portusjacksoni that catalyses the sulfation of the shark bile steroid 5 beta-scymnol". Comp. Biochem. Physiol. B. 107 (3): 461–9. doi:10.1016/0305-0491(94)90212-7. PMID 7749614.
- ↑ Pettigrew NE, Wright PF, Macrides TA (1998). "Investigation of 5beta-scymnol sulfotransferase from the kidney and testes of Heterodontus portusjacksoni". Comp. Biochem. Physiol. 121 (3): 243–249. doi:10.1016/S0305-0491(98)10097-4.
- ↑ Pettigrew NE, Wright PF, Macrides TA (1998). "5beta-Scymnol sulfotransferase isolated from the tissues of an Australian shark species". Comp. Biochem. Physiol. 121 (3): 299–307. doi:10.1016/S0305-0491(98)10103-7.
- ↑ Pettigrew NE, Wright PF, Macrides TA (1998). "5beta-scymnol sulfotransferase isolated from the liver of two Australian ray species". Comp. Biochem. Physiol. 121: 341–348. doi:10.1016/S0305-0491(98)10116-5.
- ↑ Enzyme 2.8.2.32 at KEGG Pathway Database.
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