Glycochenodeoxycholate sulfotransferase
| Glycochenodeoxycholate sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.2.34 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Glycochenodeoxycholate sulfotransferase (EC 2.8.2.34) is an enzyme that catalyzes the chemical reaction
+ PAPS
glycochenodeoxycholic acid 7-sulfate
+ adenosine 3',5'-
bisphosphate
bisphosphate
The enzyme characterised from hamsters uses the cofactor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to convert the bile acid, glycochenodeoxycholic acid, to its sulfate derivative, giving adenosine 3',5'-bisphosphate as a byproduct.[1][2]
Nomenclature
This enzyme is a transferase, specifically a sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase. Other names in common use include bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase, bile acid:PAPS:sulfotransferase, and BAST.[3]
See also
- Bile salt sulfotransferase which acts on a wider range of substrates in a similar reaction
References
- ↑ Barnes S, Burhol PG, Zander R, Haggstrom G, Settine RL, Hirschowitz BI (November 1979). "Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters". Journal of Lipid Research. 20 (8): 952–9. doi:10.1016/S0022-2275(20)39996-X. PMID 533830.
- ↑ Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annual Review of Biochemistry. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
- ↑ Enzyme 2.8.2.34 at KEGG Pathway Database.