Cortisol sulfotransferase
| Cortisol sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.2.18 | ||||||||
| CAS no. | 71427-08-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Cortisol sulfotransferase (EC 2.8.2.18) is an enzyme that catalyzes the chemical reaction
The reaction converts the steroid hormone, cortisol, to its sulfate derivative by transferring a sulfate group from the cofactor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) and giving adenosine 3',5'-bisphosphate as a byproduct. The enzyme was characterised from liver.[1][2]
This enzyme is a transferase, specifically a sulfotransferase, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase. Other names in common use include glucocorticosteroid sulfotransferase, and glucocorticoid sulfotransferase.[3]
References
- ↑ Singer SS, Giera D, Johnson J, Sylvester S (1976). "Enzymatic sulfation of steroids: I. The enzymatic basis for the sex difference in cortisol sulfation by rat liver preparations". Endocrinology. 98 (4): 963–74. doi:10.1210/endo-98-4-963. PMID 1278101.
- ↑ Singer SS, Brill B (1982). "Enzymatic sulfation of steroids. XVII. The properties of the glucocorticoid sulfotransferase activity of guinea pig liver cytosol". Biochim. Biophys. Acta. 712 (3): 590–6. doi:10.1016/0005-2760(82)90287-9. PMID 6957246.
- ↑ Enzyme 2.8.2.18 at KEGG Pathway Database.