Psychosine sulfotransferase
| Psychosine sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.8.2.13 | ||||||||
| CAS no. | 37259-76-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Psychosine sulfotransferase (EC 2.8.2.13) is an enzyme that catalyzes the chemical reaction:
The reaction converts the cytotoxic lipid psychosine, derived from sphingosine, to a sulfate product by transferring a sulfate group from the cofactor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) and giving adenosine 3',5'-bisphosphate as a byproduct. The enzyme was characterised from mouse brain.[1]
This enzyme is a transferase, specifically a sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:galactosylsphingosine sulfotransferase. Other names in common use include PAPS:psychosine sulphotransferase, and 3'-phosphoadenosine 5'-phosphosulfate-psychosine sulphotransferase.[2]
References