Choline sulfotransferase

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Choline sulfotransferase
Choline sulfotransferase
Identifiers
EC no.	2.8.2.6
CAS no.	9047-23-8
Databases
BRENDA	enzyme data
ExPASy	NiceZyme view
KEGG	enzyme entry
MetaCyc	metabolic pathway
Rhea	reactions
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

Choline sulfotransferase (EC 2.8.2.6) is an enzyme that catalyzes the chemical reaction

choline

+

2D representation of the chemical structure of 3'-Phosphoadenosine-5'-phosphosulfate.

PAPS

2D representation of the chemical structure of Q27102096.

choline sulfate

+

adenosine 3',5'-bisphosphate

The reaction converts choline to choline sulfate by transferring a sulfate group from the cofactor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) and giving adenosine 3',5'-bisphosphate as a byproduct.^[1]^[2] The product is an osmolyte accumulated under saline conditions in organisms including Limonium species.^[3]^[4]

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:choline sulfotransferase. This enzyme is also called choline sulphokinase.^[5]

References

↑ Orsi, Bruno A.; Spencer, Brian (1964). "Choline Sulphokinase (Sulphotransferase)**". The Journal of Biochemistry. 56: 81–91. doi:10.1093/oxfordjournals.jbchem.a127963. PMID 14202240.
↑ Schomburg, Dietmar; Stephan, Dörte (1997). "Choline sulfotransferase". Enzyme Handbook. pp. 935–938. doi:10.1007/978-3-642-59025-2_173. ISBN 978-3-642-47773-7.
↑ Rivoal, J.; Hanson, A. D. (1994). "Choline-O-Sulfate Biosynthesis in Plants (Identification and Partial Characterization of a Salinity-Inducible Choline Sulfotransferase from Species of Limonium (Plumbaginaceae)". Plant Physiology. 106 (3): 1187–1193. doi:10.1104/pp.106.3.1187. PMC 159648. PMID 12232402.
↑ Anjum, Naser A.; Thangavel, Palaniswamy; Rasheed, Faisal; Masood, Asim; Pirasteh-Anosheh, Hadi; Khan, Nafees A. (2023). "Osmolytes". Global Climate Change and Plant Stress Management. pp. 399–409. doi:10.1002/9781119858553.ch27. ISBN 978-1-119-85852-2.
↑ Enzyme 2.8.2.6 at KEGG Pathway Database.

[1] Orsi, Bruno A.; Spencer, Brian (1964). "Choline Sulphokinase (Sulphotransferase)**". The Journal of Biochemistry. 56: 81–91. doi:10.1093/oxfordjournals.jbchem.a127963. PMID 14202240.

[2] Schomburg, Dietmar; Stephan, Dörte (1997). "Choline sulfotransferase". Enzyme Handbook. pp. 935–938. doi:10.1007/978-3-642-59025-2_173. ISBN 978-3-642-47773-7.

[3] Rivoal, J.; Hanson, A. D. (1994). "Choline-O-Sulfate Biosynthesis in Plants (Identification and Partial Characterization of a Salinity-Inducible Choline Sulfotransferase from Species of Limonium (Plumbaginaceae)". Plant Physiology. 106 (3): 1187–1193. doi:10.1104/pp.106.3.1187. PMC 159648. PMID 12232402.

[4] Anjum, Naser A.; Thangavel, Palaniswamy; Rasheed, Faisal; Masood, Asim; Pirasteh-Anosheh, Hadi; Khan, Nafees A. (2023). "Osmolytes". Global Climate Change and Plant Stress Management. pp. 399–409. doi:10.1002/9781119858553.ch27. ISBN 978-1-119-85852-2.

[5] Enzyme 2.8.2.6 at KEGG Pathway Database.

[1]

[2]

[3]

[4]

[5]

Transferases: sulfur-containing group (EC 2.8)
2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase lipoyl synthase molybdenum cofactor sulfurtransferase thiazole synthase molybdopterin synthase sulfurtransferase molybdopterin synthase tRNA-uridine 2-sulfurtransferase () tRNA-5-taurinomethyluridine 2-sulfurtransferase () tRNA-5-methyluridine⁵⁴ 2-sulfurtransferase () L-aspartate semialdehyde sulfurtransferase ()
2.8.2: Sulfotransferases	aryl sulfotransferase amine sulfotransferase estrone sulfotransferase chondroitin 4-sulfotransferase choline sulfotransferase UDP-N-acetylgalactosamine-4-sulfate sulfotransferase heparan sulfate-glucosamine N-sulfotransferase tyrosine-ester sulfotransferase Renilla-luciferin sulfotransferase galactosylceramide sulfotransferase psychosine sulfotransferase bile salt sulfotransferase steroid sulfotransferase thiol sulfotransferase chondroitin 6-sulfotransferase cortisol sulfotransferase triglucosylalkylacylglycerol sulfotransferase protein-tyrosine sulfotransferase keratan sulfotransferase aryl-sulfate sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 1 desulfoglucosinolate sulfotransferase flavonol 3-sulfotransferase quercetin-3-sulfate 3′-sulfotransferase quercetin-3-sulfate 4′-sulfotransferase quercetin-3,3′-bissulfate 7-sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 2 (heparan sulfate)-glucosamine 3-sulfotransferase 3 petromyzonol sulfotransferase scymnol sulfotransferase N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase glycochenodeoxycholate sulfotransferase dermatan 4-sulfotransferase desulfo-A47934 sulfotransferase () trehalose 2-sulfotransferase () aliphatic desulfoglucosinolate sulfotransferase () hydroxyjasmonate sulfotransferase () ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase (*) Alcohol sulfotransferase Tyrosylprotein sulfotransferase
2.8.3: CoA-transferases	Propionate CoA-transferase oxalate CoA-transferase malonate CoA-transferase 3-oxoacid CoA-transferase 3-oxoadipate CoA-transferase succinyl-CoA—Dcitramalate CoA-transferase acetate CoA-transferase butyrate—acetoacetate CoA-transferase citrate CoA-transferase citramalate CoA-transferase glutaconate CoA-transferase succinate—hydroxymethylglutarate CoA-transferase 5-hydroxypentanoate CoA-transferase succinyl-CoA:(R)-benzylsuccinate CoA-transferase formyl-CoA transferase cinnamoyl-CoA:phenyllactate CoA-transferase succinyl-CoA:acetate CoA-transferase () CoA:oxalate CoA-transferase () succinyl-CoA—D-citramalate CoA-transferase () L-carnitine CoA-transferase () succinyl-CoA—L-malate CoA-transferase () caffeate CoA-transferase () (R)-2-hydroxy-4-methylpentanoate CoA-transferase () bile acid CoA-transferase () succinyl-CoA:mesaconate CoA transferase (*)
2.8.4: Alkylthio	2.8.4: Coenzyme-B sulfoethylthiotransferase arsenate-mycothiol transferase tRNA-2-methylthio-N⁶-dimethylallyladenosine synthase () [ribosomal protein S12] (aspartate⁸⁹-C³)-methylthiotransferase () tRNA (N⁶-L-threonylcarbamoyladenosine³⁷-C²)-methylthiotransferase (*)
2.8.5:	2.8.5: S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent) () L-cysteine S-thiosulfotransferase ()

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)