Quercetin-3-sulfate 4'-sulfotransferase

Quercetin-3-sulfate 4'-sulfotransferase
Identifiers
EC no.2.8.2.27
CAS no.121855-12-7
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Quercetin-3-sulfate 4'-sulfotransferase (EC 2.8.2.27) is an enzyme that catalyzes the chemical reaction

+ PAPS
 
 
 
 
Rightward reaction arrow
 
 
 
2D representation of the chemical structure of Q27102774.
quercetin 3,4'-bissulfate
+ adenosine 3',5'-
bisphosphate
 

It uses the cofactor 3'-phosphoadenosine-5'-phosphosulfate (PAPS) to transfer a sulfate group and gives adenosine 3',5'-bisphosphate as a byproduct. The enzyme characterised from Flaveria chlorifolia converts quercetin 3-O-sulfate to quercetin 3,4'-bissulfate. The starting material is produced from quercetin by a similar reaction catalysed by the enzyme flavonol 3-sulfotransferase.[1]

This enzyme is transferase, specifically a sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:quercetin-3-sulfate 3'-sulfotransferase. Other names in common use include flavonol 3'-sulfotransferase, 3'-Sulfotransferase, and PAPS:flavonol 3-sulfate 3'-sulfotransferase.[2]

References

  1. ↑ Varin L, Ibrahim RK (July 1989). "Partial Purification and Characterization of Three Flavonol-Specific Sulfotransferases from Flaveria chlorifolia". Plant Physiology. 90 (3): 977–81. doi:10.1104/pp.90.3.977. PMC 1061831. PMID 16666908.
  2. ↑ Enzyme 2.8.2.27 at KEGG Pathway Database.