Isoflavone 3'-hydroxylase
| Isoflavone 3'-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.88 | ||||||||
| CAS no. | 110183-50-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Isoflavone 3'-hydroxylase (EC 1.14.14.88, Formerly EC 1.14.13.52) is an enzyme that catalyzes the chemical reaction
Isoflavone 3'-hydroxylase is a cytochrome P450 protein containing heme. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate (NADPH). The systematic name of this enzyme class is formononetin,NADPH:oxygen oxidoreductase (3'-hydroxylating). It is also called isoflavone 3'-monooxygenase.[1]
The enzyme isolated from chickpea is part of the biosynthetic pathway to pterocarpans which act as phytoalexins.[2]
References
- ↑ Enzyme 1.14.14.88 at KEGG Pathway Database.
- ↑ Hinderer W, Flentje U, Barz W (1987). "Microsomal isoflavone 2'-hydroxylases and 3'-hydroxylases from chickpea (Cicer arietinum L) cell-suspensions induced for pterocarpan phytoalexin formation". FEBS Lett. 214: 101–106. doi:10.1016/0014-5793(87)80021-2.