(S)-corytuberine synthase
| (S)-corytuberine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.19.51 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
(S)-corytuberine synthase is an enzyme purified from the plant Coptis japonica (Japanese goldthread),[1] with EC number EC 1.14.19.51 and CYP Symbol CYP80G2. It catalyses an intramolecular C-C phenol coupling of (S)-reticuline to (S)-corytuberine in a pathway leading to magnoflorine.[2][3]
-reticuline.svg.png)
-corytuberine.svg.png)
(S)-corytuberine synthase is a cytochrome P450 protein containing heme. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate (NADPH).[4]
References
- ↑ Ikezawa N, Iwasa K, Sato F (April 2008). "Molecular cloning and characterization of CYP80G2, a cytochrome P450 that catalyzes an intramolecular C-C phenol coupling of (S)-reticuline in magnoflorine biosynthesis, from cultured Coptis japonica cells". The Journal of Biological Chemistry. 283 (14): 8810–21. Bibcode:2008JBiCh.283.8810I. doi:10.1074/jbc.M705082200. PMID 18230623.
- ↑ Meelaph T, Kobtrakul K, Chansilpa NN, Han Y, Rani D, De-Eknamkul W, Vimolmangkang S (August 2018). "Coregulation of Biosynthetic Genes and Transcription Factors for Aporphine-Type Alkaloid Production in Wounded Lotus Provides Insight into the Biosynthetic Pathway of Nuciferine". ACS Omega. 3 (8): 8794–8802. doi:10.1021/acsomega.8b00827. PMC 6644620. PMID 31459012.
- ↑ Tian Y, Kong L, Li Q, Wang Y, Wang Y, An Z, Ma Y, Tian L, Duan B, Sun W, Gao R, Chen S, Xu Z (November 2024). "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids". Natural Product Reports. 41 (11): 1787–1810. doi:10.1039/d4np00029c. PMID 39360417.
- ↑ Enzyme 1.14.19.51 at KEGG Pathway Database.
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