Benzoate 4-monooxygenase
| Benzoate 4-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.92 | ||||||||
| CAS no. | 39391-25-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Benzoate 4-monooxygenase (EC 1.14.14.92, Formerly EC 1.14.13.12) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are benzoic acid, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are 4-hydroxybenzoic acid, oxidised NADP+, and water.[1][2]
The enzyme is a cytochrome P450 protein containing heme. It requires a partner, cytochrome P450 reductase, using NADPH for functional expression. The systematic name of this enzyme class is benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use include benzoic acid 4-hydroxylase, benzoate 4-hydroxylase, benzoic 4-hydroxylase, benzoate-p-hydroxylase, and p-hydroxybenzoate hydroxylase. It participates in benzoate degradation via hydroxylation.[1]
References
- 1 2 Enzyme 1.14.14.92 at KEGG Pathway Database.
- ↑ Reddy CC, Vaidyanathan CS (1975). "Purification, properties and induction of a specific benzoate-4-hydroxylase from Aspergillus niger (UBC 814)". Biochim. Biophys. Acta. 384 (1): 46–57. doi:10.1016/0005-2744(75)90094-7. PMID 236777.