Trans-cinnamate 4-monooxygenase
| Trans-cinnamate 4-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.91 | ||||||||
| CAS no. | 9077-75-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Trans-cinnamate 4-monooxygenase (EC 1.14.14.91) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are cinnamic acid, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are p-coumaric acid, oxidised NADP+, and water. It participates in phenylalanine metabolism and phenylpropanoid biosynthesis, especially of flavonoids in plants.[1][2][3]
The enzyme is a cytochrome P450 protein containing heme. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate (NADPH).[4]
Nomenclature
The systematic name of this enzyme class is trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use include:[4]
- cinnamic acid 4-hydroxylase,
- oxygenase, cinnamate 4-mono-,
- CA4H (gene name),
- CYP73A1 (gene name),
- cytochrome P450 cinnamate 4-hydroxylase,
- cinnamate 4-hydroxylase,
- cinnamate 4-monooxygenase,
- cinnamate hydroxylase,
- cinnamic 4-hydroxylase,
- cinnamic acid 4-monooxygenase,
- cinnamic acid p-hydroxylase,
- hydroxylase, cinnamate 4-,
- t-cinnamic acid hydroxylase,
- trans-cinnamate 4-hydroxylase, and
- trans-cinnamic acid 4-hydroxylase.
References
- ↑ Potts JR, Weklych R, Conn EE, Rowell J (1974). "The 4-hydroxylation of cinnamic acid by sorghum microsomes and the requirement for cytochrome P-450". J. Biol. Chem. 249 (16): 5019–26. doi:10.1016/S0021-9258(19)42322-3. PMID 4153152.
- ↑ Russell DW, Conn EE (1967). "The cinnamic acid 4-hydroxylase of pea seedlings". Arch. Biochem. Biophys. 122 (1): 256–8. doi:10.1016/0003-9861(67)90150-6. PMID 4383827.
- ↑ Petersen M (May 2003). "Cinnamic acid 4-hydroxylase from cell cultures of the hornwort Anthoceros agrestis". Planta. 217 (1): 96–101. Bibcode:2003Plant.217...96P. doi:10.1007/s00425-002-0960-9. PMID 12721853.
- 1 2 Enzyme 1.14.14.91 at KEGG Pathway Database.