| February (6–4) |
| Date |
Opponent |
Rank |
Site/stadium |
Score |
Win |
Loss |
Save |
TV |
Attendance |
Overall record |
SBC record |
| Feb. 13 | Fairfield* | No. 6 | Springs Brooks Stadium • Conway, SC | W 5–3 | Horn (1–0) | Miller | None | ESPN+ | 5,499 | 1–0 | |
| Feb. 14 (DH 1) | Farfield* | No. 6 | Springs Brooks Stadium • Conway, SC | W 5–1 | Norman (1–0) | Grabmann | None | ESPN+ | 3,329 | 2–0 | |
| Feb. 14 (DH 2) | Farfield* | No. 6 | Springs Brooks Stadium • Conway, SC | W 5–0 | Doran (1–0) | Sheldon | Bosch (1) | ESPN+ | 3–0 | |
| Feb. 17 | College of Charleston* | No. 6 | Springs Brooks Stadium • Conway, SC | L 3–4 | Rogers | Richardson (0–1) | None | ESPN+ | 3,933 | 3–1 | |
| Baseball at the Beach |
| Feb. 20 | VCU* | No. 6 | Springs Brooks Stadium • Conway, SC | W 13–28 | Bosch (1–0) | Weygandt | None | ESPN+ | 4,011 | 4–1 | |
| Feb. 21 | Illinois* | No. 6 | Springs Brooks Stadium • Conway, SC | Cancelled (inclement weather) |
| Feb. 22 (DH 1) | Illinois* | No. 6 | Springs Brooks Stadium • Conway, SC | L 5–14 | Hall | Norman (1–1) | Remington | ESPN+ | 2,296 | 4–2 | |
| Feb. 22 (DH 2) | VCU* | No. 6 | Springs Brooks Stadium • Conway, SC | W 6–3 | Horn (2–0) | Gotschall | None | ESPN+ | 2,623 | 5–2 | |
| Feb. 24 | Campbell* | No. 9 | Springs Brooks Stadium • Conway, SC | W 13–7 | Doran (2–0) | Simmons | None | ESPN+ | 2,769 | 6–2 | |
| Astros Foundation College Classic |
| Feb. 27 | vs. No. 3 Texas* | No. 9 | Daikin Park • Houston, TX | L 1–8 | Riojas | Jones (0–1) | None | YouTube | 13,427 | 6–3 | |
| Feb. 28 | vs. UTSA* | No. 9 | Daikin Park • Houston, TX | L 10–16 | Qualia | Norman (1–2) | None | YouTube | 12,219 | 6–4 | |
| March (15–3) |
| Date |
Opponent |
Rank |
Site/stadium |
Score |
Win |
Loss |
Save |
TV |
Attendance |
Overall record |
SBC record |
| Astros Foundation College Classic |
| Mar. 1 | vs. No. 25 Ole Miss* | No. 9 | Daikin Park • Houston, TX | W 9–2 | Doran (3–0) | Libbert | Horn (1) | YouTube | — | 7–4 | |
| Mar. 3 | at No. 13 NC State* | No. 16 | Doak Field • Raleigh, NC | L 4–6 | Black | Kane (0–1) | None | ACCNX | 2,806 | 7–5 | |
| Mar. 6 | East Carolina* | No. 16 | Springs Brooks Stadium • Conway, SC | W 10–610 | Richardson (1–1) | Rose | None | ESPN+ | 3,872 | 8–5 | |
| Mar. 7 | East Carolina* | No. 16 | Springs Brooks Stadium • Conway, SC | W 7–1 | Norman (2–2) | Antolick | None | ESPN+ | 4,362 | 9–5 | |
| Mar. 8 | East Carolina* | No. 16 | Springs Brooks Stadium • Conway, SC | L 4–106 | Moran | Doran (3–1) | None | ESPN+ | 3,567 | 9–6 | |
| Mar. 10 | No. 12 Wake Forest* | No. 16 | Springs Brooks Stadium • Conway, SC | W 10–4 | Kane (1–1) | Bowie | None | ESPN+ | 5,122 | 10–6 | |
| Mar. 13 | at App State | No. 16 | Beaver Field at Jim and Bettie Smith Stadium • Boone, NC | W 10–6 | Horn (3–0) | Smith | None | ESPN+ | 480 | 11–6 | 1–0 |
| Mar. 14 | at App State | No. 16 | Beaver Field at Jim and Bettie Smith Stadium • Boone, NC | W 7–4 | Lynch (0–1) | Tramontana | Doran (1) | ESPN+ | 1,119 | 12–6 | 2–0 |
| Mar. 15 | at App State | No. 16 | Beaver Field at Jim and Bettie Smith Stadium • Boone, NC | W 8–7 | Richardson (2–1) | Clark | Horn (2) | ESPN+ | 373 | 13–6 | 3–0 |
| Mar. 18 | at Campbell* | No. 16 | Jim Perry Stadium • Buies Creek, NC | L 3–4 | Clark | Doran (3–2) | None | FloCollege | 698 | 13–7 | |
| Mar. 20 | James Madison | No. 16 | Springs Brooks Stadium • Conway, SC | W 12–27 | Jones (1–1) | Kuhle | Horn (3) | ESPN+ | 5,067 | 14–7 | 4–0 |
| Mar. 21 | James Madison | No. 16 | Springs Brooks Stadium • Conway, SC | W 10–07 | Norman (3–2) | Alexander | None | ESPN+ | 5,068 | 15–7 | 5–0 |
| Mar. 22 | James Madison | No. 16 | Springs Brooks Stadium • Conway, SC | W 16–67 | Doran (4–2) | Lutz | None | ESPN+ | 3,589 | 16–7 | 6–0 |
| Mar. 24 | at Clemson* | No. 15 | Doug Kingsmore Stadium • Clemson, SC | W 11–9 | Horn (3–0) | Nelson | None | ACC Network | 4,934 | 17–7 | |
| Mar. 27 | at Marshall | No. 15 | Jack Cook Field • Huntington, WV | W 11–9 | Parker (1–0) | Blevins | Lynch (1) | ESPN+ | 1,556 | 18–7 | 7–0 |
| Mar. 28 | at Marshall | No. 15 | Jack Cook Field • Huntington, WV | W 12–4 | Norman (4–2) | Harlow | Horn (4) | ESPN+ | 1,671 | 19–7 | 8–0 |
| Mar. 29 | at Marshall | No. 15 | Jack Cook Field • Huntington, WV | W 5–410 | Lynch (2–0) | Baird | None | ESPN+ | 1,528 | 20–7 | 9–0 |
| Mar. 31 | at The Citadel* | No. 14 | Joseph P. Riley Jr. Park • Charleston, SC | W 3–2 | Richardson (3–1) | Van Slooten | Doran (2) | ESPN+ | 2,259 | 21–7 | |
| April (10–6) |
| Date |
Opponent |
Rank |
Site/stadium |
Score |
Win |
Loss |
Save |
TV |
Attendance |
Overall record |
SBC record |
| Apr. 2 | South Alabama | No. 14 | Springs Brooks Stadium • Conway, SC | W 12–27 | Jones (2–1) | Heer | None | ESPN+ | 4,614 | 22–7 | 10–0 |
| Apr. 3 | South Alabama | No. 14 | Springs Brooks Stadium • Conway, SC | L 2–15 | Shineflew | Norman (4–3) | None | ESPN+ | 4,137 | 22–8 | 10–1 |
| Apr. 4 | South Alabama | No. 14 | Springs Brooks Stadium • Conway, SC | W 8–7 | Richardson (4–0) | Garmon II | None | ESPN+ | | 23–8 | 11–1 |
| Apr. 7 | vs Wake Forest* | No. 11 | Durham Bulls Athletic Park • Durham, NC | W 2–1 | Bosch (2–0) | Marsten | Lynch (2) | ACCNX | 1,059 | 24–8 | |
| Apr. 10 | at Arkansas State | No. 11 | Tomlinson Stadium–Kell Field • Jonesboro, AR | W 10–7 | Kane (2–1) | Foss | Lynch (3) | ESPN+ | 1,374 | 25–8 | 12–1 |
| Apr. 11 | at Arkansas State | No. 11 | Tomlinson Stadium–Kell Field • Jonesboro, AR | W 4–3 | Horn (5–0) | Maloney | Lynch (4) | ESPN+ | 2,112 | 26–8 | 13–1 |
| Apr. 12 | at Arkansas State | No. 11 | Tomlinson Stadium–Kell Field • Jonesboro, AR | L 3–6 | Farley | Appelman (0–1) | Garrison | ESPN+ | 863 | 26–9 | 13–2 |
| Apr. 14 | at Wake Forest* | No. 7 | David F. Couch Ballpark • Winston-Salem, NC | L 5–10 | Marsten | Smallets (0–1) | None | ACCNX | 2,428 | 26–10 | |
| Apr. 17 | Georgia State | No. 7 | Springs Brooks Stadium • Conway, SC | W 15–7 | Jones (3–1) | Crooms | None | ESPN+ | 3,809 | 27–10 | 14–2 |
| Apr. 18 | Georgia State | No. 7 | Springs Brooks Stadium • Conway, SC | W 7–2 | Norman (5–3) | Caruso | Horn (5) | ESPNU | 3,854 | 28–10 | 15–2 |
| Apr. 19 | Georgia State | No. 7 | Springs Brooks Stadium • Conway, SC | L 5–11 | Bartkowski | Lynch (2–1) | None | ESPN+ | N/A | 28–11 | 15–3 |
| Apr. 21 | at UNC Wilmington | No. 9 | Brooks Field • Wilmington, NC | L 1–2 | Thompson | Horn (5–1) | None | FloCollege | 1,944 | 28–12 | |
| Apr. 24 | Texas State | No. 9 | Springs Brooks Stadium • Conway, SC | W 6–2 | Jones (4–1) | Cooper | None | ESPN+ | 3,567 | 29–12 | 16–3 |
| Apr. 25 | Texas State | No. 9 | Springs Brooks Stadium • Conway, SC | W 2–1 | Horn (6–1) | Froehlich | None | ESPN+ | 3,623 | 30–12 | 17–3 |
| Apr. 26 | Texas State | No. 9 | Springs Brooks Stadium • Conway, SC | L 6–10 | Kebrow | Appleman (0–2) | None | ESPN+ | 3,367 | 30–13 | 17–4 |
| Apr. 28 | at No. 2 North Carolina | No. 9 | Boshamer Stadium • Chapel Hill, NC | W 12–2 | Parker (2–0) | McDuffie | None | ACC Network | 4,405 | 31–13 | |
| May (5–6) |
| Date |
Opponent |
Rank |
Site/stadium |
Score |
Win |
Loss |
Save |
TV |
Attendance |
Overall record |
SBC record |
| May 1 | at Georgia Southern | No. 9 | J. I. Clements Stadium • Statesboro, GA | W 8–7 | Kane (3–1) | Pendley | Horn (6) | ESPN+ | 1,990 | 32–13 | 18–4 |
| May 3 (DH 1) | at Georgia Southern | No. 9 | J. I. Clements Stadium • Statesboro, GA | W 14–47 | Norman (6–3) | Holder | Horn (7) | ESPN+ | 2,392 | 33–13 | 19–4 |
| May 3 (DH 2) | at Georgia Southern | No. 9 | J. I. Clements Stadium • Statesboro, GA | L 4–7 | Mason | Flukey (0–1) | None | ESPN+ | 2,405 | 33–14 | 19–5 |
| May 5 | Clemson | No. 8 | Springs Brooks Stadium • Conway, SC | L 4–8 | Titsworth | Smallets (0–2) | None | ESPN+ | 6,103 | 33–15 | |
| May 8 | Old Dominion | No. 8 | Springs Brooks Stadium • Conway, SC | W 16–8 | Parker (3–0) | Kuskie | None | ESPN+ | 3,395 | 34–15 | 20–5 |
| May 9 | Old Dominion | No. 8 | Springs Brooks Stadium • Conway, SC | L 3–6 | Tanton | Norman (6–4) | None | ESPN+ | 3,377 | 34–16 | 20–6 |
| May 10 | Old Dominion | No. 8 | Springs Brooks Stadium • Conway, SC | L 2–9 | Sulpizio | Flukey (0–2) | None | ESPN+ | 3,315 | 34–17 | 20–7 |
| May 12 | The Citadel | No. 20 | Springs Brooks Stadium • Conway, SC | W 5–3 | Bosch (3–0) | Coulter | Lynch (5) | ESPN+ | 3,314 | 35–17 | |
| May 14 | at Louisiana | No. 20 | M. L. Tigue Moore Field at Russo Park • Lafayette, LA | L 2–7 | Brasch | Jones (4–2) | None | ESPN+ | 4,612 | 35–18 | 20–8 |
| May 15 | at Louisiana | No. 20 | M. L. Tigue Moore Field at Russo Park • Lafayette, LA | W 6–0 | Horn (7–1) | Herrmann | None | ESPN+ | 5,026 | 36–18 | 21–8 |
| May 16 | at Louisiana | No. 20 | M. L. Tigue Moore Field at Russo Park • Lafayette, LA | L 2–3 | Roman | Norman (6–5) | Papenbrock | ESPN+ | 4,936 | 36–19 | 21–9 |
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