Sarcosine oxidase

sarcosine oxidase
Identifiers
EC no.1.5.3.1
CAS no.9029-22-5
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Sarcosine oxidase is an enzyme (EC 1.5.3.1) that catalyzes the oxidative demethylation of sarcosine to yield glycine.[1]

+ H2O
 
 
O2
H2O2
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
 

The enzyme uses flavin adenine dinucleotide as a cofactor and oxygen is required, which is converted to hydrogen peroxide. The methyl group of sarcosine leaves as formaldehyde. Corynebacterial sarcosine oxidase is a heterotetramer and is produced as an inducible enzyme when Corynebacterium sp.is grown with sarcosine as source of carbon and energy.[2]

Further reading

  1. ↑ Enzyme 1.5.3.1 at KEGG Pathway Database.
  2. ↑ Suzuki H (February 1994). "Sarcosine oxidase: structure, function, and the application to creatinine determination". Amino Acids. 7 (1): 27–43. doi:10.1007/BF00808444. PMID 24185971.