Mannosylfructose-phosphate synthase
| Mannosylfructose-phosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.246 | ||||||||
| CAS no. | 92480-04-1 (not distinguished from EC 2.4.1.167) | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Mannosylfructose-phosphate synthase (EC 2.4.1.246, mannosylfructose-6-phosphate synthase, MFPS) is an enzyme with systematic name GDP-mannose:D-fructose-6-phosphate 2-alpha-D-mannosyltransferase.[1] This enzyme catalyses the following chemical reaction
.svg.png)
-phosphate.svg.png)
The enzyme transfers a mannose sugar unit from GDP-mannose to a specific hydroxy group in fructose 6-phosphate (shown in its open-chain form) to give the product disaccharide, with guanosine diphosphate (GDP) as byproduct. It was characterised from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, and requires magnesium Mg2+ or manganese Mn2+ ions for activity. The product is hydrolysed by the enzyme mannosylfructose-phosphate phosphatase to give an osmolyte which protects the organism from osmotic shock.[2]
References
- ↑ Enzyme 2.4.1.246 at KEGG Pathway Database.
- ↑ Torres LL, Salerno GL (September 2007). "A metabolic pathway leading to mannosylfructose biosynthesis in Agrobacterium tumefaciens uncovers a family of mannosyltransferases". Proceedings of the National Academy of Sciences of the United States of America. 104 (36): 14318–23. Bibcode:2007PNAS..10414318T. doi:10.1073/pnas.0706709104. PMC 1964871. PMID 17728402.
External links
- Mannosylfructose-phosphate+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Category: