Mannosylfructose-phosphate phosphatase

Mannosylfructose-phosphate phosphatase
Identifiers
EC no.3.1.3.79
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

Mannosylfructose-phosphate phosphatase (EC 3.1.3.79, mannosylfructose-6-phosphate phosphatase, MFPP) is an enzyme with systematic name β-D-ructofuranosyl-α-D-mannopyranoside-6F-phosphate phosphohydrolase.[1] It catalyses the following chemical reaction which removes a phosphate group (Pi) by hydrolysis:

2D representation of the chemical structure of Q27122804.
β-D-fructofuranosyl-α-D-mannopyranoside 6F-phosphate
 
H2O
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q27122800.
β-D-fructofuranosyl-α-D-mannopyranoside

This enzyme, from the soil proteobacterium and plant pathogen Agrobacterium tumefaciens strain C58, requires magnesium, Mg2+, for activity. The starting material is produced from GDP-mannose and fructose 6-phosphate by the enzyme mannosylfructose-phosphate synthase and the product is an osmolyte which protexts the organism from osmotic shock.[2]

References

  1. ↑ Enzyme 3.1.3.79 at KEGG Pathway Database.
  2. ↑ Torres LL, Salerno GL (September 2007). "A metabolic pathway leading to mannosylfructose biosynthesis in Agrobacterium tumefaciens uncovers a family of mannosyltransferases". Proceedings of the National Academy of Sciences of the United States of America. 104 (36): 14318–23. Bibcode:2007PNAS..10414318T. doi:10.1073/pnas.0706709104. PMC 1964871. PMID 17728402.