Uracil phosphoribosyltransferase
| Uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | UPRT | ||||||
| NCBI gene | 139596 | ||||||
| HGNC | 28334 | ||||||
| RefSeq | NM_145052 | ||||||
| UniProt | Q96BW1 | ||||||
| Other data | |||||||
| Locus | Chr. X q13.3 | ||||||
| |||||||
| Uridine phosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.2.9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Uracil phosphoribosyltransferase is an enzyme which interconverts uridine monophosphate with uracil and phosphoribosyl pyrophosphate. In the forward direction shown, pyrophosphoric acid is added to the ribose sugar unit to cleave off the attached heterocycle.[1][2]
This protein is thought to use the morpheein model of allosteric regulation.[3]
References
- ↑ Enzyme 2.4.2.9 at KEGG Pathway Database.
- ↑ Crawford, I; Kornberg, A; Simms, ES (1957). "Conversion of uracil and orotate to uridine 5'-phosphate by enzymes in lactobacilli" (pdf). Journal of Biological Chemistry. PMID 13438895.
- ↑ Selwood T, Jaffe EK (March 2012). "Dynamic dissociating homo-oligomers and the control of protein function". Archives of Biochemistry and Biophysics. 519 (2): 131–43. doi:10.1016/j.abb.2011.11.020. PMC 3298769. PMID 22182754.
External links
- Uracil+phosphoribosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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