Mannosyl-3-phosphoglycerate synthase
| Mannosyl-3-phosphoglycerate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.217 | ||||||||
| CAS no. | 393512-63-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Mannosyl-3-phosphoglycerate synthase (EC 2.4.1.217) is an enzyme that catalyzes the chemical reaction
-3-phosphoglyceric_acid.svg.png)
The two substrates of this enzyme characterised from Pyrococcus horikoshii are 3-phospho-D-glyceric acid and GDP-mannose. Its products are 2-(α-D-mannosyl)-3-phosphoglyceric acid (mannosyl-3-phosphoglycerate) and guanosine diphosphate (GDP). In this thermophilic bacteria, the product has its phosphate group removed by hydrolysis by the enzyme mannosyl-3-phosphoglycerate phosphatase. This gives a compound, mannosylglycerate, which acts to protect against osmotic shock.[1]
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase. This enzyme is also called MPG synthase.[2]
References
- ↑ Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS (2001). "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes". J. Biol. Chem. 276 (47): 43580–8. doi:10.1074/jbc.M108054200. hdl:10362/191445. PMID 11562374.
- ↑ Enzyme 2.4.1.217 at KEGG Pathway Database.
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