Mannosyl-3-phosphoglycerate phosphatase
| Mannosyl-3-phosphoglycerate phosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.3.70 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme mannosyl-3-phosphoglycerate phosphatase (EC 3.1.3.70) catalyzes a chemical reaction which removes a phosphate group (Pi) by hydrolysis:
-3-phosphoglyceric_acid.svg.png)
-D-glyceric_acid.svg.png)
The enzyme was characterised in the thermophilic bacteria, Pyrococcus horikoshii, and the product 2-(α-D-mannosyl)-D-glyceric acid (mannosylglycerate) helps prevent osmotic shock.[1]
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is 2-O-(α-D-mannosyl)-3-phosphoglycerate phosphohydrolase.[2]
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 1WZC and PDB: 1XVI.
References
- ↑ Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS (2001). "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes". J. Biol. Chem. 276 (47): 43580–8. doi:10.1074/jbc.M108054200. hdl:10362/191445. PMID 11562374.
- ↑ Enzyme 3.1.3.70 at KEGG Pathway Database.
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