ABHD6

ABHD6
Identifiers
Aliases	ABHD6, abhydrolase domain containing 6, abhydrolase domain containing 6, acylglycerol lipase
External IDs	OMIM: 616966; MGI: 1913332; GeneCards: ABHD6
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	58,295,693 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	14,466,871 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; jejunal mucosa; ; lateral nuclear group of thalamus; ; corpus callosum; ; C1 segment; ; endothelial cell; ; cerebellar vermis; ; right lobe of liver; ; duodenum; ; external globus pallidus;
	Top expressed in
	motor neuron; ; adrenal gland; ; facial motor nucleus; ; Rostral migratory stream; ; anterior horn of spinal cord; ; duodenum; ; lateral geniculate nucleus; ; dentate gyrus of hippocampal formation granule cell; ; left lobe of liver; ; pontine nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	catalytic activity; hydrolase activity; acylglycerol lipase activity; phospholipase activity;
Cellular component	integral component of membrane; plasma membrane; AMPA glutamate receptor complex; membrane; mitochondrion; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic membrane; lysosomal membrane; late endosome membrane; lysosome; endosome; mitochondrial membranes;
Biological process	acylglycerol catabolic process; negative regulation of cell migration; positive regulation of lipid biosynthetic process; regulation of endocannabinoid signaling pathway; phospholipid catabolic process; long-term depression; negative regulation of cold-induced thermogenesis; monoacylglycerol catabolic process; lysobisphosphatidic acid metabolic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57406
	66082
	ENSG00000163686
	ENSMUSG00000025277
	Q9BV23
	Q8R2Y0
	NM_020676; NM_001320126
	NM_025341; NM_001331064; NM_001331065
	NP_001307055; NP_065727; NP_065727.4; NP_001307055.1
	NP_001317993; NP_001317994; NP_079617
	Wikidata
View/Edit Human	View/Edit Mouse

alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase, is an enzyme that in humans is encoded by the ABHD6 gene.

Function

ABHD6 is a serine hydrolyzing enzyme that possesses typical α/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms of tumours.^[5]

ABHD6 has been linked to regulation of the endocannabinoid system as it controls the accumulation of 2-arachidonoylglycerol (2-AG) at the cannabinoid receptors.^[6]

ABHD6 accounts for about 4% of 2-AG brain hydrolysis.^[7] Together, monoacylglycerol lipase (MAGL), ABHD12, and ABHD6 control about 99% of 2-AG signalling in the brain,^[7]^[8] and each enzyme exhibits a distinct subcellular distribution, suggesting that they regulate distinct pools of 2-AG in the nervous system.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163686 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025277 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Li F, Fei X, Xu J, Ji C (April 2009). "An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines". Molecular Biology Reports. 36 (4): 691–6. doi:10.1007/s11033-008-9230-7. PMID 18360779. S2CID 6795598.
↑ Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Möller T, Mackie K, Manzoni OJ, Cravatt BF, Stella N (August 2010). "The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors". Nature Neuroscience. 13 (8): 951–7. doi:10.1038/nn.2601. PMC 2970523. PMID 20657592.
1 2 Cannabinoid Receptors—Advances in Research and Application: 2012 Edition: ScholarlyBrief. ScholarlyEditions. 26 December 2012. pp. 68–. ISBN 978-1-4816-0672-1.
↑ Savinainen JR, Saario SM, Laitinen JT (February 2012). "The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors". Acta Physiologica. 204 (2): 267–76. doi:10.1111/j.1748-1716.2011.02280.x. PMC 3320662. PMID 21418147.
↑ Blankman JL, Simon GM, Cravatt BF (December 2007). "A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol". Chemistry & Biology. 14 (12): 1347–56. doi:10.1016/j.chembiol.2007.11.006. PMC 2692834. PMID 18096503.

External links

Human ABHD6 genome location and ABHD6 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163686 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025277 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid18360779-5] Li F, Fei X, Xu J, Ji C (April 2009). "An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines". Molecular Biology Reports. 36 (4): 691–6. doi:10.1007/s11033-008-9230-7. PMID 18360779. S2CID 6795598.

[pmid20657592-6] Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Möller T, Mackie K, Manzoni OJ, Cravatt BF, Stella N (August 2010). "The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors". Nature Neuroscience. 13 (8): 951–7. doi:10.1038/nn.2601. PMC 2970523. PMID 20657592.

[ScholarlyEditions2012-7] 1 2 Cannabinoid Receptors—Advances in Research and Application: 2012 Edition: ScholarlyBrief. ScholarlyEditions. 26 December 2012. pp. 68–. ISBN 978-1-4816-0672-1.

[pmid21418147-8] Savinainen JR, Saario SM, Laitinen JT (February 2012). "The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors". Acta Physiologica. 204 (2): 267–76. doi:10.1111/j.1748-1716.2011.02280.x. PMC 3320662. PMID 21418147.

[9] Blankman JL, Simon GM, Cravatt BF (December 2007). "A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol". Chemistry & Biology. 14 (12): 1347–56. doi:10.1016/j.chembiol.2007.11.006. PMC 2692834. PMID 18096503.

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Function

See also

References

External links