Uridine kinase
| Uridine kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Uridine-cytidine kinase 2, tetramer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.1.48 | ||||||||
| CAS no. | 9026-39-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Uridine kinase (EC 2.7.1.48) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from an ascites tumor and Escherichia coli converts uridine to uridine monophosphate and cytidine to cytidine monophosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1][2] The enzyme occurs widely, including in yeasts, humans and plants.[3][4][5]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:uridine 5'-phosphotransferase. Other names in common use include pyrimidine ribonucleoside kinase, uridine-cytidine kinase, uridine kinase (phosphorylating), and uridine phosphokinase.[6]
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1UDW, PDB: 1UEI, PDB: 1UEJ, PDB: 1UFQ, PDB: 1UJ2, PDB: 1XRJ, PDB: 2JEO, and PDB: 2UVQ.
References
- ↑ Orengo, A (April 1969). "Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor". The Journal of Biological Chemistry. 244 (8): 2204–9. doi:10.1016/S0021-9258(18)94384-X. PMID 5782006.
- ↑ Valentin-Hansen, Poul (1978). "Uridine-cytidine kinase from Escherichia coli". Purine and Pyrimidine Nucleotide Metabolism. Methods in Enzymology. Vol. 51. pp. 308–314. doi:10.1016/s0076-6879(78)51041-0. ISBN 978-0-12-181951-4. PMID 211379.
- ↑ Kern, Laurence (1990). "The URK1 gene of Saccharomyces cerevisiae encoding uridine kinase". Nucleic Acids Research. 18 (17): 5279. doi:10.1093/nar/18.17.5279. PMC 332152. PMID 2169608.
- ↑ Van Rompay, An R.; Norda, Ameli; Lindén, Karin; Johansson, Magnus; Karlsson, Anna (2001). "Phosphorylation of Uridine and Cytidine Nucleoside Analogs by Two Human Uridine-Cytidine Kinases". Molecular Pharmacology. 59 (5): 1181–1186. doi:10.1124/mol.59.5.1181. PMID 11306702.
- ↑ Ohler, Lisa; Niopek-Witz, Sandra; Mainguet, Samuel E.; Möhlmann, Torsten (2019). "Pyrimidine Salvage: Physiological Functions and Interaction with Chloroplast Biogenesis". Plant Physiology. 180 (4): 1816–1828. doi:10.1104/pp.19.00329. PMC 6670073. PMID 31101721.
- ↑ Enzyme 2.7.1.48 at KEGG Pathway Database.
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