Thiamine-diphosphate kinase
| Thiamine-diphosphate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.4.15 | ||||||||
| CAS no. | 9075-79-0 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thiamine-diphosphate kinase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction
The enzyme characterised from maize converts thiamine pyrophosphate to thiamine triphosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1][2]
Nomenclature
The enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:thiamine-diphosphate phosphotransferase. Other names in common use include ATP:thiamin-diphosphate phosphotransferase, TDP kinase, thiamin diphosphate kinase, thiamin diphosphate phosphotransferase, thiamin pyrophosphate kinase, thiamine diphosphate kinase, and protein bound thiamin diphosphate:ATP phosphoryltransferase.[3]
See also
References
- ↑ Itokawa Y, Cooper JR (1968). "The enzymatic synthesis of triphosphothiamin". Biochim. Biophys. Acta. 158 (1): 180–2. doi:10.1016/0304-4165(68)90093-7. PMID 5661031.
- ↑ Kikuchi M; Ikawa T (1984). "Presence of an enzyme mediating transfer of phosphate from thiamine triphosphate to ADP in germinating maize". Bot. Mag. 97 (2). Tokyo: 193–205. Bibcode:1984JPlR...97..193K. doi:10.1007/BF02488693.
- ↑ Enzyme 2.7.4.15 at KEGG Pathway Database.