Urate-ribonucleotide phosphorylase
| Urate-ribonucleotide phosphorylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.2.16 | ||||||||
| CAS no. | 9030-29-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Urate-ribonucleotide phosphorylase (EC 2.4.2.16) is an enzyme that catalyzes the phosphorolysis reaction
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The two substrates of this enzyme found in the small intestine of dogs are 3-(β-D-ribofuranosyl)uric acid and orthophosphate (Pi). Its products are α-D-ribose 1-phosphate and uric acid. Enzyme activity in the direction from uric acid to its nucleotide was not shown.[1]
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is urate-ribonucleotide:phosphate alpha-D-ribosyltransferase. Other names in common use include UAR phosphorylase, and urate-ribonucleotide:phosphate D-ribosyltransferase.[2]
References
- ↑ Laster L, Blair A (October 1963). "An intestinal phosphorylase for uric acid ribonucleoside". The Journal of Biological Chemistry. 238 (10): 3348–57. doi:10.1016/S0021-9258(18)48671-1. PMID 14085385.
- ↑ Enzyme 2.4.2.16 at KEGG Pathway Database.
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