+ reduced
acceptor
Uracil/thymine dehydrogenase
| Uracil/thymine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.17.99.4 | ||||||||
| CAS no. | 9029-00-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Uracil/thymine dehydrogenase (EC 1.17.99.4, uracil oxidase, uracil-thymine oxidase, uracil dehydrogenase) is an enzyme with systematic name uracil:acceptor oxidoreductase.[1][2][3][4] This enzyme catalyses two related chemical reactions:
In a similar way, thymine is converted to 5-methylbarbituric acid. The enzyme forms part of the oxidative pyrimidine-degrading pathway in some microorganisms.[5][6]
References
- ↑ Hayaishi O, Kornberg A (May 1952). "Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes". The Journal of Biological Chemistry. 197 (2): 717–32. doi:10.1016/S0021-9258(18)55628-3. PMID 12981104.
- ↑ Wang TP, Lampen JO (February 1952). "Metabolism of pyrimidines by a soil bacterium". The Journal of Biological Chemistry. 194 (2): 775–83. doi:10.1016/S0021-9258(18)55832-4. PMID 14927671.
- ↑ Wang TP, Lampen JO (February 1952). "Uracil oxidase and the isolation of barbituric acid from uracil oxidation". The Journal of Biological Chemistry. 194 (2): 785–91. doi:10.1016/S0021-9258(18)55833-6. PMID 14927672.
- ↑ Lara FJ (August 1952). "On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations". Journal of Bacteriology. 64 (2): 279–85. doi:10.1128/jb.64.2.279-285.1952. PMC 169350. PMID 14955523.
- ↑ Enzyme 1.17.99.4 at KEGG Pathway Database.
- ↑ Soong CL, Ogawa J, Shimizu S (August 2001). "Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase". Biochemical and Biophysical Research Communications. 286 (1): 222–6. Bibcode:2001BBRC..286..222S. doi:10.1006/bbrc.2001.5356. PMID 11485332.
External links
- Uracil/thymine+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Category: