Columbamine oxidase
| Columbamine oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.21.3.2 | ||||||||
| CAS no. | 95329-18-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Columbamine oxidase (EC 1.21.3.2) is an enzyme that catalyzes the chemical reaction that converts the benzylisoquinoline alkaloid, columbamine, into berberine.
The two substrates of this enzyme are columbamine and oxygen. Its products are berberine and water.[1]
This enzyme is an oxidoreductases, specifically those acting on X-H and Y-H to form an X-Y bond with oxygen as acceptor. The systematic name of this enzyme class is columbamine:oxygen oxidoreductase (cyclizing). This enzyme is also called berberine synthase. This enzyme participates in alkaloid biosynthesis. It employs one cofactor, iron.[2]
References