UTP—hexose-1-phosphate uridylyltransferase
| UTP:galactose-1-phosphate uridylyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 UTP—galactose-1-phosphate uridylyltransferase homodimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.7.10 | ||||||||
| CAS no. | 9016-11-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
UTP—hexose-1-phosphate uridylyltransferase (EC 2.7.7.10) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Bifidobacterium bifidum and Entamoeba histolytica combines uridine triphosphate and galactose 1-phosphate to give uridine diphosphate galactose, with pyrophosphate (PPi) as a byproduct.[1][2][3][4]
Nomenclature
This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UTP:alpha-D-hexose-1-phosphate uridylyltransferase. Other names in common use include galactose-1-phosphate uridylyltransferase, galactose 1-phosphate uridylyltransferase, alpha-D-galactose 1-phosphate uridylyltransferase, galactose 1-phosphate uridyltransferase, UDPgalactose pyrophosphorylase, uridine diphosphate galactose pyrophosphorylase, and uridine diphosphogalactose pyrophosphorylase.[5]
Structural studies
As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes PDB: 1GUP, PDB: 1GUQ, and PDB: 1HXP.
References
- ↑ Isselbacher KJ (1958). "A mammalian uridinediphosphate galactose pyrophosphorylase". J. Biol. Chem. 232 (1): 429–44. doi:10.1016/S0021-9258(18)70408-0. PMID 13549431.
- ↑ Kalckar HM (1953). "The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides". Biochim. Biophys. Acta. 12 (1–2): 250–64. doi:10.1016/0006-3002(53)90144-9. PMID 13115434.
- ↑ Lee L, Kimura A, Tochikura T (October 1979). "Purification and properties of UDP-glucose (UDP-galactose) pyrophosphorylase from Bifidobacterium bifidum". J. Biochem. 86 (4). Tokyo: 923–8. doi:10.1093/oxfordjournals.jbchem.a132624. PMID 500588.
- ↑ Lobelle-Rich PA, Reeves RE (1983). "Separation and characterization of two UTP-utilizing hexose phosphate uridylyltransferases from Entamoeba histolytica". Mol. Biochem. Parasitol. 7 (2): 173–82. doi:10.1016/0166-6851(83)90043-9. PMID 6304512.
- ↑ Enzyme 2.7.7.10 at KEGG Pathway Database.