Taxoid 7beta-hydroxylase
| Taxoid 7beta-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.182 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Taxoid 7beta-hydroxylase (EC 1.14.14.182) is an enzyme with systematic name taxusin,NADPH:oxygen 7-oxidoreductase.[1] This enzyme catalyses the following chemical reaction
The three substrates of this enzyme are taxusin, oxygen, and a proton. It uses a reduced nicotinamide adenine dinucleotide (NADH) cofactor bound to a heme in cytochrome P450 to give 7β-hydroxytaxusin and water as products.[2]
The enzyme is found in the yew tree Taxus cuspidata and is part of the pathway for the biosynthesis of taxol.[1]
References
- 1 2 Chau M, Jennewein S, Walker K, Croteau R (May 2004). "Taxol biosynthesis: Molecular cloning and characterization of a cytochrome P450 taxoid 7 beta-hydroxylase". Chemistry & Biology. 11 (5): 663–72. doi:10.1016/j.chembiol.2004.02.025. PMID 15157877.
- ↑ Enzyme 1.14.14.182 at KEGG Pathway Database.
External links
- Taxoid+7beta-hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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