Tatenale virus
| Orthohantavirus tatenalense | |
|---|---|
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| Microtus agrestis, the natural reservoir of Orthohantavirus tatenalense | |
Virus classification  | |
| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Negarnaviricota |
| Class: | Bunyaviricetes |
| Order: | Elliovirales |
| Family: | Hantaviridae |
| Genus: | Orthohantavirus |
| Species: | Orthohantavirus tatenalense |
Tatenale virus (TATV), formally Orthohantavirus tatenalense, is a species of hantavirus first identified in 2013 in a field vole near Tattenhall, Cheshire, in northwest England.[1] Its name derives from Tattenhall's medieval Latin name. It is one of two hantaviruses known to circulate in the United Kingdom, the other being Seoul virus carried by brown rats.[2]
Virology
The Tatenale virus has a negative-sense single-stranded RNA genome as with other orthohantaviruses. Phylogenetic analyses shows partial affinity with other vole-related hantaviruses, namely Prospect Hill virus and Tula virus.[3]
Strains
Recovery of coding sequences in 2020 confirmed that Tatenale virus and the "Traemersee virus" found in Germany in 2019 are members of the same viral species, with evolutionary distance values below the speciation threshold of 0.1; the species name Tatenale orthohantavirus was proposed on this basis, given the earlier detection and greater establishment in the literature of the Tatenale designation.[2] The "Rusne virus" a hantavirus strain found in 2021 in a Lithuanian vole was later classified by the ICTV as being a Tatenale strain, while also stating that the name "Rusne virus" should no longer be used.
Natural reservoir
The reservoir of Tatenale virus is the field vole.[2] A survey of field voles in Kielder Forest, Northumberland, recorded a prevalence of approximately 17%, or 8 out of 48 animals.[4] It has not been found in other rodents in England.[2]
Zoonosis
No zoonotic potential has been confirmed for Tatenale virus.[5] However, blood from the originally infected vole showed cross-reactivity with Puumala virus antigen, which is another vole-related hantavirus. Potentially, some serologically diagnosed cases of hemorrhagic fever with renal syndrome attributed to Puumala virus in England could actually be Tatenale infections, mayhaps.[3][2]
See also
References
- ↑ Pounder, K.C.; Begon, M.; Sironen, T.; Henttonen, H.; Watts, P.C.; Voutilainen, L. (2013). "Novel Hantavirus in Wildlife, United Kingdom". Emerging Infectious Diseases. 19 (4): 673–675. doi:10.3201/eid1904.121057. PMC 3647411. PMID 23750506.
- 1 2 3 4 5 Chappell, J.G.; Tsoleridis, T.; Onianwa, O. o (2020). "Retrieval of the Complete Coding Sequence of the UK-Endemic Tatenale Orthohantavirus Reveals Extensive Strain Variation and Supports its Classification as a Novel Species". Viruses. 12 (4): 454. doi:10.3390/v12040454. PMC 7232349. PMID 32316655.
- 1 2 Pounder, K.C.; Begon, M.; Sironen, T.; et al. (2013). "Novel Hantavirus in Wildlife, United Kingdom". Emerging Infectious Diseases. 19 (4): 673–675. doi:10.3201/eid1904.121057. PMC 3647411. PMID 23750506.
- ↑ Thomason, A.G.; Begon, M.; Bradley, J.E.; Paterson, S.; Jackson, J.A. (2017). "Endemic Hantavirus in Field Voles, Northern England". Emerging Infectious Diseases. 23 (6): 1033–1035. doi:10.3201/eid2306.161607. PMC 5443433. PMID 28518021.
- ↑ "Hantaviruses". University of Nottingham OneVir Research Group. Retrieved 18 May 2026.
Until recently, the UK was thought to only have the Seoul hantavirus carried by brown rats. Our work, along with that of others, has demonstrated that we have a second hantavirus, named tatenale virus, that is carried by field voles (Microtus agrestis). We do not yet know if this virus also infects humans but given its genetic relationship to other European hantaviruses (such as Puumula virus carried by bank voles in other parts of Europe) it is likely to and this is an area of future research.