Tabersonine 16-hydroxylase
| Tabersonine 16-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.103 | ||||||||
| CAS no. | 250378-34-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Tabersonine 16-hydroxylase (EC 1.14.14.103) is an enzyme that catalyzes the chemical reaction
Tabersonine 16-hydroxylase is a cytochrome P450 protein containing heme, isolated from Catharanthus roseus. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate. The systematic name of this enzyme class is tabersonine,NADPH:oxygen oxidoreductase (16-hydroxylating). Other names in common use include tabersonine-11-hydroxylase, and T11H. It participates in indole alkaloid biosynthesis leading to vindoline.[1][2][3]
References
- ↑ Enzyme 1.14.14.103 at KEGG Pathway Database.
- ↑ St-Pierre B, De Luca V (1995). "A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus". Plant Physiol. 109 (1): 131–139. doi:10.1104/pp.109.1.131. PMC 157569. PMID 12228585.
- ↑ Demars, Matthew D.; o'Connor, Sarah E. (2024). "Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis". Proceedings of the National Academy of Sciences. 121 (7) e2318586121. doi:10.1073/pnas.2318586121. PMID 38319969.