T2-induced deoxynucleotide kinase
| T2-induced deoxynucleotide kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.4.12 | ||||||||
| CAS no. | 37278-99-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
T2-induced deoxynucleotide kinase (EC 2.7.4.12) is an enzyme that catalyzes two related chemical reactions. The first converts the nucleotide, deoxyguanosine monophosphate, to deoxyguanosine diphosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1]
Similarly, thymidine monophosphate is converted to thymidine diphosphate:[1]
The enzyme was characterised from Escherichia coli infected with the virus, enterobacteria phage T2, and carried out these reactions at rates up to 20 times those of uninfected cells.[1]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:(d)NMP phosphotransferase.[2]
References
- 1 2 3 Bello, Leonard J.; Bessman, Maurice J. (1963). "The Enzymology of Virus-infected Bacteria". Journal of Biological Chemistry. 238 (5): 1777–1787. doi:10.1016/S0021-9258(18)81137-1.
- ↑ Enzyme 2.7.4.12 at KEGG Pathway Database.