Sym-norspermidine synthase
| Sym-norspermidine synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.23 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Sym-norspermidine synthase (EC 2.5.1.23) is an enzyme characterised from Euglena gracilis that catalyzes a chemical reaction which transfers a propylamine three-carbon unit from S-adenosylmethioninamine to 1,3-diaminopropane, forming norspermidine, and giving 5′-methylthioadenosine as a byproduct:[1][2] The enzyme found in Sulfolobus solfataricus can use other amines including putrescine as its substrate.[3]
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This enzyme is a transferase, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosylmethioninamine:propane-1,3-diamine 3-aminopropyltransferase. This enzyme participates in the urea cycle.[4]
References
- ↑ Aleksijevic A, Grove J, Schuber F (1979). "Studies on polyamine biosynthesis in Euglena gracilis". Biochim. Biophys. Acta. 565 (1): 199–207. doi:10.1016/0005-2787(79)90096-0. PMID 116684.
- ↑ Villanueva VR, Adlakha RC, Calbayrac R (1980). "Biosynthesis of polyamines in Euglena gracilis". Phytochemistry. 19 (5): 787–790. Bibcode:1980PChem..19..787V. doi:10.1016/0031-9422(80)85111-9.
- ↑ Cacciapuoti, Giovanna; Porcelli, Marina; Carteni-Farina, Maria; Gambacorta, Agata; Zappia, Vincenzo (1986). "Purification and characterization of propylamine transferase from Sulfolobus solfataricus, an extreme thermophilic archaebacterium". European Journal of Biochemistry. 161 (2): 263–271. doi:10.1111/j.1432-1033.1986.tb10442.x. PMID 3096734.
- ↑ Enzyme 2.5.1.23 at KEGG Pathway Database.