Sucrose synthase
| Sucrose synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.13 | ||||||||
| CAS no. | 9030-05-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| Sucrose synthase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | Sucrose_synth | ||||||
| Pfam | PF00862 | ||||||
| InterPro | IPR000368 | ||||||
| |||||||
Sucrose synthase (EC 2.4.1.13) is an enzyme that catalyzes the chemical reaction
-sucrose.svg.png)
The two substrates of this enzyme are NDP-glucose and D-fructose. Its products are nucleoside diphosphate (NDP) and sucrose. It has been characterised from many plants, including beet,[2][3] rice,[4] mung bean,[5][6] broad bean,[7] and Japanese pear.[8] The related enzyme from the cyanobacteria genus Anabaena has different substrate affinity owing to its N-terminal sequence.[9]
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase. Other names in common use include UDPglucose-fructose glucosyltransferase, sucrose synthetase, sucrose-UDP glucosyltransferase, sucrose-uridine diphosphate glucosyltransferase, and uridine diphosphoglucose-fructose glucosyltransferase.[10] This enzyme participates in starch and sucrose metabolism.[11]
References
- ↑ Zheng, Yi; Spencer, A.; Zhang, Y.; Garavito, R.M. (24 August 2011). "The Structure of Sucrose Synthase-1 from Arabidopsis thaliana and its Functional Implications". Journal of Biological Chemistry. 286 (41): 36108–36118. doi:10.1074/jbc.M111.275974. PMC 3195635. PMID 21865170.; rendered with PyMOL
- ↑ Avigad G; Milner Y (1966). "UDP-glucose: Fructose transglucosylase from sugar beet roots". UDP-glucose:fructose transglucosylase from sugar beet roots. Methods Enzymol. Vol. 8. pp. 341–345. doi:10.1016/0076-6879(66)08063-7. ISBN 978-0-12-181808-1.
- ↑ Silvius JE; Snyder FW (1979). "Comparative enzymic studies of sucrose metabolism in the taproots and fibrous roots of Beta vulgaris L". Plant Physiol. 64 (6): 1070–1073. doi:10.1104/pp.64.6.1070. PMC 543193. PMID 16661094.
- ↑ Murata T, Sugiyama T, Minamikawa T, Akazawa T (1966). "Enzymic mechanism of starch synthesis in ripening rice grains. 3 Mechanism of the sucrose-starch conversion". Arch. Biochem. Biophys. 113 (1): 34–44. doi:10.1016/0003-9861(66)90153-6. PMID 5941994.
- ↑ Delmer DP (1972). "The purification and properties of sucrose synthetase from etiolated Phaseolus aureus seedlings". J. Biol. Chem. 247 (12): 3822–8. doi:10.1016/S0021-9258(19)45108-9. PMID 4624446.
- ↑ Yoshinaga F, Mori H, Sakai F, Hayashi T (1998). "An increase in apparent affinity for sucrose of mung bean sucrose synthase is caused by in vitro phosphorylation or directed mutagenesis of Ser11". Plant Cell Physiol. 39 (12): 1337–41. doi:10.1093/oxfordjournals.pcp.a029339. PMID 10050318.
- ↑ Ross, HA, Davies HV (1992). "Purification and characterization of sucrose synthase from the cotyledons of Vicia fava L". Plant Physiol. 100 (2): 1008–1013. doi:10.1104/pp.100.2.1008. PMC 1075657. PMID 16653008.
- ↑ Tanase K, Yamaki S (2000). "Purification and characterization of two sucrose synthase isoforms from Japanese pear fruit". Plant Cell Physiol. 41 (4): 408–14. doi:10.1093/pcp/41.4.408. PMID 10845453.
- ↑ Porchia AC, Curatti L, Salerno GL (1999). "Sucrose metabolism in cyanobacteria: sucrose synthase from Anabaena sp. strain PCC 7119 is remarkably different from the plant enzymes with respect to substrate affinity and amino-terminal sequence". Planta. 210 (1): 34–40. Bibcode:1999Plant.210...34P. doi:10.1007/s004250050651. PMID 10592030.
- ↑ Enzyme 2.4.1.13 at KEGG Pathway Database.
- ↑ T, Pozueta-Romero J; Muñoz, FJ; Saikusa, T; Rodríguez-López, M; Akazawa, T; Pozueta-Romero, J (2003). "Sucrose synthase catalyzes the de novo production of ADPglucose linked to starch biosynthesis in heterotrophic tissues of plants". Plant Cell Physiol. 44 (5): 500–9. doi:10.1093/pcp/pcg062. PMID 12773636.
Category: