Succinyl-CoA hydrolase
| Succinyl-CoA hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.2.3 | ||||||||
| CAS no. | 9025-86-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme succinyl-CoA hydrolase (EC 3.1.2.3) catalyzes the reaction
The enzyme characterised from pig heart hydrolyses succinyl-CoA to coenzyme A and succinic acid.[1][2] The enzyme and succinic acid are part of the citric acid cycle.[3]
This enzyme is a hydrolase, specifically one acting on thioester bonds. The systematic name is succinyl-CoA hydrolase. Other names in common use include succinyl-CoA acylase, succinyl coenzyme A hydrolase, and succinyl coenzyme A deacylase.[4]
References
- ↑ Gergely, J.; Hele, P.; Ramakrishnan, C.V. (1952). "Succinyl and Acetyl Coenzyme a Deacylases". Journal of Biological Chemistry. 198: 323–334. doi:10.1016/S0021-9258(18)55586-1. PMID 12999747.
- ↑ Schomburg, Dietmar; Salzmann, Margit (1991). "Succinyl-CoA hydrolase". Enzyme Handbook 3. pp. 237–239. doi:10.1007/978-3-642-76463-9_52. ISBN 978-3-642-48962-4.
- ↑ Correa, Paulo Renato A.V.; Kruglov, Emma A.; Thompson, Mayerson; Leite, M. Fatima; Dranoff, Jonathan A.; Nathanson, Michael H. (2007). "Succinate is a paracrine signal for liver damage". Journal of Hepatology. 47 (2): 262–269. doi:10.1016/j.jhep.2007.03.016. PMC 1986575. PMID 17451837.
- ↑ Enzyme 3.1.2.3 at KEGG Pathway Database.
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