Streptomycin 3"-kinase
| streptomycin 3"-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.87 | ||||||||
| CAS no. | 39391-15-6 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a streptomycin 3"-kinase (EC 2.7.1.87) is an enzyme that catalyzes the chemical reaction
- ATP + streptomycin ADP + streptomycin 3"-phosphate
The enzyme characterised from Streptomyces bacteria converts the antibiotic, streptomycin, to a monophosphate, streptomycin 3''-phosphate, by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1]
This enzyme is a transferases, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:streptomycin 3"-phosphotransferase. Other names in common use include streptomycin 3"-kinase (phosphorylating), and streptomycin 3"-phosphotransferase.[2]
References
- ↑ Walker JB, Skorvaga M (1973). "Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives". J. Biol. Chem. 248 (7): 2435–40. doi:10.1016/S0021-9258(19)44127-6. PMID 4121456.
- ↑ Enzyme 2.7.1.87 at KEGG Pathway Database.
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