Sodium butyrate

Sodium butyrate
Names
	Preferred IUPAC name Sodium butanoate
	Other names Sodium butyrate
Identifiers
CAS Number	156-54-7 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:64103 ;
ChEMBL	ChEMBL62381 ;
ChemSpider	8727 ;
ECHA InfoCard	100.005.326
PubChem CID	5222465;
UNII	8RAS91C36W ;
CompTox Dashboard (EPA)	DTXSID3037672 ;
	InChI InChI=1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1;
	SMILES CCCC(=O)[O-].[Na+];
Properties
Chemical formula	CH3CH2CH2COONa
Molar mass	110.088 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Sodium butyrate is a compound with formula CH₃CH₂CH₂COO⁻Na⁺.^[1] It is the sodium salt of butyric acid. It is a white, water-soluble, crystalline solid having the odor of butyric acid.^[1]

Occurrence

Sodium butyrate is a common source of butyrate which forms when butyric acid is dissolved near neutral pH.^[1] Butyrate is a common metabolite that is produced by hydrolysis of butyryl-CoA.^[2]

Medical research

Butyrate affects histone deacetylase, which is tied to DNA processing.^[3] Sodium butyrate is under preliminary research for its potential to mitigate traveler's diarrhea.^[4]

References

1 2 3 "Sodium butyrate". PubChem, US National Library of Medicine. 11 July 2026. Retrieved 13 July 2026.
↑ Nelson, David L.; Cox, Michael M. (2005). Principles of Biochemistry (4th ed.). New York: W. H. Freeman. ISBN 0-7167-4339-6.
↑ Davie, James R. (2003). "Inhibition of Histone Deacetylase Activity by Butyrate". The Journal of Nutrition. 133 (7): 2485S–2493S. doi:10.1093/jn/133.7.2485s. PMID 12840228.
↑ Fan H, Gao L, Yin Z, Ye S, Zhao H, Peng Q (October 2022). "Probiotics and rifaximin for the prevention of travelers' diarrhea: A systematic review and network meta-analysis". Medicine (Baltimore). 101 (40) e30921. doi:10.1097/MD.0000000000030921. PMC 9542755. PMID 36221413.

[pubchem-1] 1 2 3 "Sodium butyrate". PubChem, US National Library of Medicine. 11 July 2026. Retrieved 13 July 2026.

[2] Nelson, David L.; Cox, Michael M. (2005). Principles of Biochemistry (4th ed.). New York: W. H. Freeman. ISBN 0-7167-4339-6.

[3] Davie, James R. (2003). "Inhibition of Histone Deacetylase Activity by Butyrate". The Journal of Nutrition. 133 (7): 2485S–2493S. doi:10.1093/jn/133.7.2485s. PMID 12840228.

[FanGaoYin2022-4] Fan H, Gao L, Yin Z, Ye S, Zhao H, Peng Q (October 2022). "Probiotics and rifaximin for the prevention of travelers' diarrhea: A systematic review and network meta-analysis". Medicine (Baltimore). 101 (40) e30921. doi:10.1097/MD.0000000000030921. PMC 9542755. PMID 36221413.

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