Simiaoa sunii
| Simiaoa sunii | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Eubacteriales |
| Family: | Lachnospiraceae |
| Genus: | Simiaoa |
| Species: | S. sunii |
| Binomial name | |
| Simiaoa sunii Liu et al. 2021 | |
Simiaoa sunii is a rod shaped bacterium that is non-mobile and is found in the gut of humans.[1][2] This species was first discovered in 2021 in a study to create a Gut Microbiome Biobank.[2][3] It was discovered in fecal samples from 239 healthy Chinese volunteers.[2] The species was named after the historical Chinese medical scientist Sun Simiao (Tang dynasty, 618–907).[2]
Taxonomy, morphology and physiology
The structure of the species is made up of 160 amino acids, has been 3D modelled and the species' DNA has been sequenced.[4] This species was grown in MGAM medium for 2–10 days at 37 °C, pH 7.0–7.5.[2]
Mitochondrial base editing
Mitochondrial base editing tools can be used to alter the function of genes by mutating a targeted DNA sequence.[5] Where methods to do this, such as CRISPR, are unable to be used alternative methods have been investigated. Researchers at Wang Yaming Laboratory at Pekings University College of the Future[6] identified a DddA homolog (Ddd_Ss) from S. sunii and was used to develop a method to mutate mtDNA loci.[5] With a further single alteration of the amino acids of Ddd_Ss, the activity and sequence compatibility of homologs from Burkholderia cenocepacia were also improved.[5]
References
- ↑ "Simiaoa sunii". NCBI. Retrieved 2026-06-24.
- 1 2 3 4 5 Liu, Chang; Du, Meng-Xuan; Abuduaini, Rexiding; Yu, Hai-Ying; Li, Dan-Hua; Wang, Yu-Jing; Zhou, Nan; Jiang, Min-Zhi; Niu, Peng-Xia; Han, Shan-Shan; Chen, Hong-He; Shi, Wen-Yu; Wu, Linhuan; Xin, Yu-Hua; Ma, Juncai (2021-05-21). "Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank". Microbiome. 9 (1): 119. doi:10.1186/s40168-021-01064-3. ISSN 2049-2618. PMC 8140505. PMID 34020714.
- ↑ "HGMB". hgmb.nmdc.cn. Retrieved 2026-06-23.
- ↑ "UniProt". UniProt. Retrieved 2026-06-23.
- 1 2 3 Mi, Li; Shi, Ming; Li, Yu-Xuan; Xie, Gang; Rao, Xichen; Wu, Damu; Cheng, Aimin; Niu, Mengxiao; Xu, Fengli; Yu, Ying; Gao, Ning; Wei, Wensheng; Wang, Xianhua; Wang, Yangming (2023-02-16). "DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing". Nature Communications. 14 (1): 874. Bibcode:2023NatCo..14..874M. doi:10.1038/s41467-023-36600-2. ISSN 2041-1723. PMC 9935910. PMID 36797253.
- ↑ "Research team identifies new mtDNA editing tool". phys.org. Archived from the original on 2023-10-09. Retrieved 2026-06-23.