Scyllo-inosamine 4-kinase
| Scyllo-inosamine 4-kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.65 | ||||||||
| CAS no. | 37278-08-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Scyllo-inosamine 4-kinase (EC 2.7.1.65) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Streptomyces bikiniensis converts 1-amino-1-deoxy-scyllo-inositol to 1-amino-1-deoxy-scyllo-inositol 4-phosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP). This reaction is part of the biosynthesis of streptomycin.[1][2]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase. Other names in common use include scyllo-inosamine kinase (phosphorylating), scyllo-inosamine kinase, and ATP:inosamine phosphotransferase.[3]
References
- ↑ Walker JB (1971). "Enzymatic reactions involved in streptomycin biosynthesis and metabolism". Lloydia. 34 (4): 363–71. PMID 4376579.
- ↑ Walker JB, Walker MS (1967). "Enzymatic synthesis of streptidine from scyllo-inosamine". Biochemistry. 6 (12): 3821–9. doi:10.1021/bi00864a028. PMID 6076630.
- ↑ Enzyme 2.7.1.65 at KEGG Pathway Database.
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