Glucose-6-phosphate exchanger SLC37A1

SLC37A1
Identifiers
Aliases	SLC37A1, G3PP, solute carrier family 37 member 1
External IDs	OMIM: 608094; MGI: 2446181; GeneCards: SLC37A1
Gene location (Human)
Chr.	Chromosome 21 (human)
End	42,581,440 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	31,569,713 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; left testis; ; right uterine tube; ; rectum; ; anterior pituitary; ; right testis; ; gallbladder; ; transverse colon; ; minor salivary glands; ; duodenum;
	Top expressed in
	colon; ; intestinal villus; ; crypt of lieberkuhn of small intestine; ; duodenum; ; left colon; ; jejunum; ; embryo; ; pyloric antrum; ; granulocyte; ; gastric mucosa;
	More reference expression data
	n/a
Gene ontology
Molecular function	transporter activity; antiporter activity; glucose 6-phosphate:inorganic phosphate antiporter activity; transmembrane transporter activity;
Cellular component	integral component of endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral component of membrane; endoplasmic reticulum membrane;
Biological process	phosphate ion transmembrane transport; carbohydrate transport; transmembrane transport; glucose-6-phosphate transport; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54020
	224674
	ENSG00000160190
	ENSMUSG00000024036
	P57057
	Q8R070
	NM_018964; NM_001320537
	NM_001242427; NM_153062
	NP_001307466; NP_061837
	NP_001229356; NP_694702
	Wikidata
View/Edit Human	View/Edit Mouse

Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene.^[5] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.^[6]

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis,^[7] but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160190 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024036 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1".
↑ "SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein".
↑ Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY (2011). "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters". PLOS ONE. 6 (9) e23157. Bibcode:2011PLoSO...623157P. doi:10.1371/journal.pone.0023157. PMC 3176764. PMID 21949678.
↑ Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME (2016). "Leveraging genetically simple traits to identify small-effect variants for complex phenotypes". BMC Genomics. 17 (1) 858. doi:10.1186/s12864-016-3175-3. PMC 5094043. PMID 27809761.

References

Further reading