SLC45A4

SLC45A4
Identifiers
Aliases	SLC45A4, solute carrier family 45 member 4
External IDs	MGI: 2146236; GeneCards: SLC45A4
Gene location (Human)
Chr.	Chromosome 8 (human)
End	141,308,305 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	73,517,611 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; endothelial cell; ; blood; ; retinal pigment epithelium; ; postcentral gyrus; ; Brodmann area 23; ; middle temporal gyrus; ; primary visual cortex; ; Achilles tendon; ; bronchial epithelial cell;
	Top expressed in
	submandibular gland; ; Epithelium of choroid plexus; ; retinal pigment epithelium; ; facial motor nucleus; ; vastus lateralis muscle; ; molar; ; triceps brachii muscle; ; extraocular muscle; ; vestibular membrane of cochlear duct; ; olfactory epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	sucrose:proton symporter activity;
Cellular component	membrane; integral component of membrane;
Biological process	sucrose transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	57210
	106068
	ENSG00000022567
	ENSMUSG00000079020
	Q5BKX6
	Q0P5V9
	NM_001080431; NM_001286646; NM_001286648
	NM_001033219; NM_001168255; NM_001357747
	NP_001073900; NP_001273575; NP_001273577
	NP_001028391; NP_001161727; NP_001344676
	Wikidata
View/Edit Human	View/Edit Mouse

SLC45A4 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, sucrose, as well simple sugars such as glucose and fructose (ii) perform secondary active transport in a proton-dependent manner.^[5]

It is associated with sugar transport in the spermatozoa.^[6] Additionally, it has been identified as a necessary component in the cell death caused of the compound paraquat.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000022567 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079020 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O (December 2014). "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae". The Biochemical Journal. 464 (2): 193–201. doi:10.1042/BJ20140572. PMID 25164149.
↑ Vitavska O, Wieczorek H (November 2017). "+/sugar cotransporter in mammalian spermatozoa". Pflügers Archiv. 469 (11): 1433–1442. doi:10.1007/s00424-017-2024-9. PMC 5629229. PMID 28689241.
↑ Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, et al. (December 2017). "A CRISPR screen identifies a pathway required for paraquat-induced cell death". Nature Chemical Biology. 13 (12): 1274–1279. doi:10.1038/nchembio.2499. PMC 5698099. PMID 29058724.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000022567 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079020 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Bartölke R, Heinisch JJ, Wieczorek H, Vitavska O (December 2014). "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae". The Biochemical Journal. 464 (2): 193–201. doi:10.1042/BJ20140572. PMID 25164149.

[6] Vitavska O, Wieczorek H (November 2017). "+/sugar cotransporter in mammalian spermatozoa". Pflügers Archiv. 469 (11): 1433–1442. doi:10.1007/s00424-017-2024-9. PMC 5629229. PMID 28689241.

[7] Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, et al. (December 2017). "A CRISPR screen identifies a pathway required for paraquat-induced cell death". Nature Chemical Biology. 13 (12): 1274–1279. doi:10.1038/nchembio.2499. PMC 5698099. PMID 29058724.

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