S-methyl-5-thioribose kinase
| S-methyl-5-thioribose kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.100 | ||||||||
| CAS no. | 68247-56-3 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
S-methyl-5-thioribose kinase (EC 2.7.1.100) is an enzyme that catalyzes the chemical reaction:
The enzyme, which is found in Enterobacter aerogenes and plants, converts S-methyl-5-thio-D-ribose to its monophosphate, S-methyl-5-thio-α-D-ribose 1-phosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1][2]
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:S-methylmethyl-5-thio-D-ribose 1-phosphotransferase. Other names in common use include 5-methylthioribose kinase (phosphorylating), methylthioribose kinase, 5-methylthioribose kinase, and ATP:S5-methyl-5-thio-D-ribose 1-phosphotransferase. This enzyme participates in methionine metabolism.[3]
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB: 2OLC, PDB: 2PU8, PDB: 2PUI, PDB: 2PUL, PDB: 2PUN, and PDB: 2PUP.
References
- ↑ Ferro AJ, Barrett A, Shapiro SK (1978). "5-Methylthioribose kinase. A new enzyme involved in the formation of methionine from 5-methylthioribose". J. Biol. Chem. 253 (17): 6021–5. doi:10.1016/S0021-9258(17)34573-8. PMID 210167.
- ↑ Guranowski A (1983). "Plant 5-methylthioribose kinase". Plant Physiol. 71 (4): 932–935. doi:10.1104/pp.71.4.932. PMC 1066146. PMID 16662931.
- ↑ Enzyme 2.7.1.100 at KEGG Pathway Database.
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