Roseburia inulinivorans
| Roseburia inulinivorans | |
|---|---|
Scientific classification  | |
| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Eubacteriales |
| Family: | Lachnospiraceae |
| Genus: | Roseburia |
| Species: | R. inulinivorans |
| Binomial name | |
| Roseburia inulinivorans Duncan et al. 2006 | |
Roseburia inulinivorans is a bacterium first isolated from human faeces. It is anaerobic, Gram-positive or Gram-variable, slightly curved rod-shaped and motile. The cells range in size from 0.5-1.5 to 5.0 micrometres. A2-194(T) (=DSM 16841(T) =NCIMB 14030(T)) is the type strain.[1] First isolated from human faeces in Aberdeen, Scotland.[1]
The abundance of Roseburia inulinivorans has been reported to decline with age and has been associated with greater muscle strength in humans. In mice, there is strong evidence that increasing its levels enhances muscle strength, likely through mechanisms involving modulation of intestinal amino acid availability, alterations in muscle purine metabolism, and an increase in type II muscle fibers. These adaptations have been associated with improvements in muscle performance, with reported increases in strength of up to 30%. However, further studies in humans are required to determine whether these effects are translatable.[2]
References
- 1 2 Sylvia H. Duncan; Rustam I. Aminov; Karen P. Scott; Petra Louis; Thaddeus B. Stanton & Harry J. Flint (October 2006). "Proposal of Roseburia faecis sp. nov., Roseburia hominis sp. nov. and Roseburia inulinivorans sp. nov., based on isolates from human faeces". International Journal of Systematic and Evolutionary Microbiology. 56 (Pt 10): 2437–2441. doi:10.1099/ijs.0.64098-0. PMID 17012576.
- ↑ Martinez-Tellez, Borja; Schönke, Milena; Kovynev, Artemiy; Garcia-Dominguez, Esther; Ortiz-Alvarez, Lourdes; Verhoeven, Aswin; Gacesa, Ranko; Vich Vila, Arnau; Ducarmon, Quinten Raymond; Jimenez-Pavon, David; Gomez-Cabrera, Maria Del Carmen; Weersma, Rinse K.; Smits, Wiep-Klaas; Giera, Martin; Ruiz, Jonatan R. (2026-03-10). "Roseburia inulinivorans increases muscle strength". Gut: gutjnl–2025–336980. doi:10.1136/gutjnl-2025-336980. hdl:1887/4307907. ISSN 1468-3288. PMID 41806991.
Further reading
- Staley, James T., et al. "Bergey's manual of systematic bacteriology, vol. 3."Williams and Wilkins, Baltimore, MD (1989): 2250–2251.
- Martínez, Inés; Lattimer, James M; Hubach, Kelcie L; Case, Jennifer A; Yang, Junyi; Weber, Casey G; Louk, Julie A; Rose, Devin J; Kyureghian, Gayaneh; Peterson, Daniel A; Haub, Mark D; Walter, Jens (2012). "Gut microbiome composition is linked to whole grain-induced immunological improvements". The ISME Journal. 7 (2): 269–280. doi:10.1038/ismej.2012.104. ISSN 1751-7362. PMC 3554403. PMID 23038174.
- Scott, K. P.; Martin, J. C.; Mrazek, J.; Flint, H. J. (2008). "Transfer of Conjugative Elements from Rumen and Human Firmicutes Bacteria to Roseburia inulinivorans". Applied and Environmental Microbiology. 74 (12): 3915–3917. Bibcode:2008ApEnM..74.3915S. doi:10.1128/AEM.02807-07. ISSN 0099-2240. PMC 2446557. PMID 18456856.
- Scott, K. P.; Martin, J. C.; Chassard, C.; Clerget, M.; Potrykus, J.; Campbell, G.; Mayer, C.-D.; Young, P.; Rucklidge, G.; Ramsay, A. G.; Flint, H. J. (2010). "Substrate-driven gene expression in Roseburia inulinivorans: Importance of inducible enzymes in the utilization of inulin and starch". Proceedings of the National Academy of Sciences. 108 (Supplement_1): 4672–4679. doi:10.1073/pnas.1000091107. ISSN 0027-8424. PMC 3063597. PMID 20679207.
- Scott, K. P.; Martin, J. C.; Campbell, G.; Mayer, C.-D.; Flint, H. J. (2006). "Whole-Genome Transcription Profiling Reveals Genes Up-Regulated by Growth on Fucose in the Human Gut Bacterium "Roseburia inulinivorans"". Journal of Bacteriology. 188 (12): 4340–4349. doi:10.1128/JB.00137-06. ISSN 0021-9193. PMC 1482943. PMID 16740940.