Ribosylnicotinamide kinase
| Ribosylnicotinamide kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.22 | ||||||||
| CAS no. | 9030-61-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Ribosylnicotinamide kinase (EC 2.7.1.22) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from liver converts the riboside, nicotinamide riboside, to the ribonucleotide, nicotinamide mononucleotide, by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1] The reaction is part of the biosynthetic pathway to the coenzyme, nicotinamide adenine dinucleotide.[2]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-ribosylnicotinamide 5'-phosphotransferase. This enzyme is also called ribosylnicotinamide kinase (phosphorylating).[3]
Food
The enzyme can be found in milk[4] and beer. Since the molecules are difficult to detect, it is expected that there are a lot more food products containing ribosylnicotinamide kinase.
References
- ↑ Rowen, John W.; Kornberg, Arthur (1951). "The Phosphorolysis of Nicotinamide Riboside". Journal of Biological Chemistry. 193 (2): 497–507. doi:10.1016/S0021-9258(18)50905-4. PMID 14907738.
- ↑ Campbell, Michael T.D.; Jones, David S.; Andrews, Gavin P.; Li, Shu (2019). "Understanding the physicochemical properties and degradation kinetics of nicotinamide riboside, a promising vitamin B3nutritional supplement". Food & Nutrition Research. 63. doi:10.29219/fnr.v63.3419. PMC 6878970. PMID 31807125.
- ↑ Enzyme 2.7.1.22 at KEGG Pathway Database.
- ↑ Bieganowski, Pawel; Brenner, Charles (2004). "Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans". Cell. 117 (4): 495–502. doi:10.1016/S0092-8674(04)00416-7. PMID 15137942.
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