Quinine 3-monooxygenase
| Quinine 3-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.55 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
A Quinine 3-monooxygenase (EC 1.14.14.55) is an enzyme that catalyzes the chemical reaction
In humans, the multi-function protein CYP3A4 catalyzes this reaction, along with many others. The four substrates of this enzyme are quinine, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are 3-hydroxyquinine, oxidised NADP+, and water.[1][2][3]
This enzyme is a cytochrome P450 protein containing heme. This oxidoreductase, which uses molecular oxygen as oxidant is in a group with systematic name quinine,NADPH:oxygen oxidoreductase. This enzyme is also called quinine 3-hydroxylase.[1] It is present in human liver, where it is involved in the metabolism of quinine.[4][5]
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1W0E, PDB: 1W0F, PDB: 1W0G, PDB: 2J0D, and PDB: 2V0M.
References
- 1 2 Enzyme 1.14.14.55 at KEGG Pathway Database.
- ↑ Relling MV, Evans R, Dass C, Desiderio DM, Nemec J (1992). "Human cytochrome P450 metabolism of teniposide and etoposide". J. Pharmacol. Exp. Ther. 261 (2): 491–6. doi:10.1016/S0022-3565(25)11065-3. PMID 1578365.
- ↑ Zhao XJ, Yokoyama H, Chiba K, Wanwimolruk S, Ishizaki T (1996). "Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450". J. Pharmacol. Exp. Ther. 279 (3): 1327–34. doi:10.1016/S0022-3565(25)21293-9. PMID 8968357.
- ↑ S; Coville, PF; Walker, RJ; Miners, JO; Birkett, DJ; Wanwimolruk, S (1997). "Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine". Br. J. Clin. Pharmacol. 43 (3): 245–52. doi:10.1046/j.1365-2125.1997.00556.x. PMC 2042745. PMID 9088578.
- ↑ Zhao XJ, Kawashiro T, Ishizaki T (1998). "Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways". Drug Metab. Dispos. 26 (2): 188–91. PMID 9456308.