+ electron
acceptor
Progesterone monooxygenase
| Progesterone monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.99.4 | ||||||||
| CAS no. | 37256-85-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Progesterone monooxygenase (EC 1.14.99.4) is an enzyme that catalyzes a chemical reaction that converts the steroid hormone, progesterone, to testosterone acetate. This is part of the mechanism that microorganisms such as Cylindrocarpon radicicola use to break down progesterone[1]
This enzyme is an oxidoreductase, that uses molecular oxygen together with an unknown electron acceptor. The systematic name of this enzyme class is progesterone,hydrogen-donor:oxygen oxidoreductase (hydroxylating). This enzyme is also called progesterone hydroxylase.[2]
References
- ↑ Rahm MA, Sih CJ (August 1966). "Mechanisms of steroid oxidation by microorganisms. XI. Enzymatic cleavage of the pregnane side chain". The Journal of Biological Chemistry. 241 (15): 3615–23. doi:10.1016/S0021-9258(18)99875-3. PMID 5950688.
- ↑ Enzyme 1.14.99.4 at KEGG Pathway Database.