Premnaspirodiene oxygenase

Premnaspirodiene oxygenase
Identifiers
EC no.1.14.14.151
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Premnaspirodiene oxygenase (EC 1.14.14.151, HPO, Hyoscymus muticus premnaspirodiene oxygenase) is an enzyme with systematic name (-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase.[1] It catalyses the following overall chemical reaction:

2D representation of the chemical structure of Q105303700.
vetispiradiene
 
2 O2
3 H2O
Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q27108304.
solavetivone

Premnaspirodiene oxygenase is a cytochrome P450 protein containing heme, isolated from Hyoscyamus muticus. It uses molecular oxygen for the oxidation, which proceeds in two steps via solavetivol, and requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate.[2]

References

  1. ↑ Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J (October 2007). "Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates". The Journal of Biological Chemistry. 282 (43): 31744–54. doi:10.1074/jbc.M703378200. PMC 2695360. PMID 17715131.
  2. ↑ Enzyme 1.14.14.151 at KEGG Pathway Database.
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