Phosphoribokinase
| Phosphoribokinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.18 | ||||||||
| CAS no. | 9030-59-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Phosphoribokinase (EC 2.7.1.18) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from rabbit converts the pentose sugar, D-ribose 5-phosphate (shown in its open-chain aldehydo form), to α-D-ribose 1,5-bisphosphate by transferring a second phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[1][2]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:D-ribose-5-phosphate 1-phosphotransferase. This enzyme is also called phosphoribokinase (phosphorylating).[3]
References
- ↑ Krebs EG (1966). "Phosphorylase b kinase from rabbit muscle". Complex Carbohydrates. Methods in Enzymology. Vol. 8. pp. 543–546. doi:10.1016/0076-6879(66)08097-2. ISBN 978-0-12-181808-1.
- ↑ Kalckar HM (1953). "The role of phosphoglycosyl compounds in the biosynthesis of nucleosides and nucleotides". Biochimica et Biophysica Acta. 12 (1–2): 250–64. doi:10.1016/0006-3002(53)90144-9. PMID 13115434.
- ↑ Enzyme 2.7.1.18 at KEGG Pathway Database.
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