Phosphoramidate—hexose phosphotransferase

phosphoramidate-hexose phosphotransferase
Identifiers
EC no.2.7.1.62
CAS no.9031-45-2
Databases
BRENDAenzyme data
ExPASyNiceZyme view
KEGGenzyme entry
MetaCycmetabolic pathway
Rheareactions
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Phosphoramidate-hexose phosphotransferase (EC 2.7.1.62) is an enzyme that catalyzes a general chemical reaction which adds a phosphate group to the 1-position of a hexose sugar:

phosphoramidate + hexose NH3 + alpha-D-hexose 1-phosphate

For example, D-gluose is converted to α-D-glucose-1-phosphate:[1]

2D representation of the chemical structure of Q23905964.
D-glucose
+ phosphoramidic acid
(HO)2P(=O)NH2
 
 
 
Rightward reaction arrow with minor product(s) to top right
 
 
 
2D representation of the chemical structure of Q418865.
α-D-glucose-1-phosphate

This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is phosphoramidate:hexose 1-phosphotransferase. Other names in common use include phosphoramidate-hexose transphosphorylase, and phosphoramidic-hexose transphosphorylase.[2]

References

  1. ↑ Smith RA, Thiesen MC (1966). "Phosphoramidate-hexose transphosphorylase". Carbohydrate Metabolism. Methods in Enzymology. Vol. 9. pp. 403–407. doi:10.1016/0076-6879(66)09082-7. ISBN 9780121818098.
  2. ↑ Enzyme 2.7.1.62 at KEGG Pathway Database.


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