Phosphomannomutase
| phosphomannomutase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 phosphomannomutase 1, dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 5.4.2.8 | ||||||||
| CAS no. | 59536-73-1 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a phosphomannomutase (EC 5.4.2.8) is an enzyme that catalyzes the chemical reaction
- alpha-D-mannose 1-phosphate D-mannose 6-phosphate
Hence, this enzyme has one substrate, alpha-D-mannose 1-phosphate, and one product, D-mannose 6-phosphate.
This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-mannose 1,6-phosphomutase. Other names in common use include mannose phosphomutase, phosphomannose mutase, and D-mannose 1,6-phosphomutase. This enzyme participates in fructose and mannose metabolism. It has 2 cofactors: D-glucose 1,6-bisphosphate, and D-Mannose 1,6-bisphosphate.
Structural studies
As of late 2007, 18 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1K2Y, PDB: 1WQA, PDB: 2AMY, PDB: 2F7L, PDB: 2FKF, PDB: 2FKM, PDB: 2FUC, PDB: 2FUE, PDB: 2H4L, PDB: 2H5A, PDB: 2I54, PDB: 2I55, and PDB: 2Q4R.
References
- Small DM, Matheson NK (1979). "Phosphomannomutase and phosphoglucomutase in developing Cassia corymbosa seeds". Phytochemistry. 18 (7): 1147–1150. Bibcode:1979PChem..18.1147S. doi:10.1016/0031-9422(79)80123-5.