Phosphoglycerate kinase (GTP)
| Phosphoglycerate kinase (GTP) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.2.10 | ||||||||
| CAS no. | 62213-34-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Phosphoglycerate kinase (GTP) (EC 2.7.2.10) is an enzyme that catalyzes the chemical reaction
The enzyme characterised from the amoebozoa, Entamoeba histolytica, converts 3-phospho-D-glyceric acid to 3-phospho-D-glyceroyl phosphate by transferring a phosphate group from the cofactor, guanosine triphosphate (GTP), which is converted to guanosine diphosphate (GDP). The enzyme is unusual since it shows selectivity for guanine nucleotides, not adenine-based ones, unlike phosphoglycerate kinase.[1]
This enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is GTP:3-phospho-D-glycerate 1-phosphotransferase.[2]
References
- ↑ Reeves RE, South DJ (1974). "Phosphoglycerate kinase (GTP). An enzyme from Entamoeba histolytica selective for guanine nucleotides". Biochem. Biophys. Res. Commun. 58 (4): 1053–7. Bibcode:1974BBRC...58.1053R. doi:10.1016/S0006-291X(74)80250-0. PMID 4365563.
- ↑ Enzyme 2.7.2.10 at KEGG Pathway Database.
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