Phenylacetone monooxygenase
| Phenylacetone monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.92 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Phenylacetone monooxygenase (EC 1.14.13.92) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are phenylacetone, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are benzyl acetate, oxidised NADP+, and water.[1][2]
This enzyme is a flavoprotein of Baeyer-Villiger monooxygenase type, which uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material.[3] The systematic name of this enzyme class is phenylacetone,NADPH:oxygen oxidoreductase. This enzyme is also called PAMO.
References
- ↑ Enzyme 1.14.13.92 at KEGG Pathway Database.
- ↑ Malito E, Alfieri A, Fraaije MW, Mattevi A (2004). "Crystal structure of a Baeyer–Villiger monooxygenase". Proc. Natl. Acad. Sci. U.S.A. 101 (36): 13157–62. Bibcode:2004PNAS..10113157M. doi:10.1073/pnas.0404538101. PMC 516541. PMID 15328411.
- ↑ DB; Wu, J; Heuts, DP; Van Hellemond, EW; Spelberg, JH; Janssen, DB (2005). "Discovery of a thermostable Baeyer-Villiger monooxygenase by genome mining". Appl. Microbiol. Biotechnol. 66 (4): 393–400. doi:10.1007/s00253-004-1749-5. PMID 15599520. S2CID 24375548.