Pantoate kinase
| Pantoate kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.7.1.169 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pantoate kinase (EC 2.7.1.169, PoK, TK2141 protein) is an enzyme with systematic name ATP:(R)-pantoate 4-phosphotransferase.[1] This enzyme catalyses the following chemical reaction
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The enzyme characterised from the archaea, Thermococcus kodakaraensis, converts (R)-pantoic acid to (R)-4-phosphopantoic acid by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).[2]
The reaction is part of the biosynthesis of phosphopantetheine.[2]
References
- ↑ Enzyme 2.7.1.169 at KEGG Pathway Database.
- 1 2 Yokooji Y, Tomita H, Atomi H, Imanaka T (October 2009). "Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea". The Journal of Biological Chemistry. 284 (41): 28137–45. doi:10.1074/jbc.m109.009696. PMC 2788864. PMID 19666462.
External links
- Pantoate+kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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